PMID- 36933249
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230512
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 29
IP  - 4
DP  - 2023 May
TI  - Value of Comprehensive Rehabilitation Therapy in Patients with Chronic 
      Obstructive Pulmonary Disease and its Effect on Improving Inflammation.
PG  - 170-176
LID - AT8005 [pii]
AB  - OBJECTIVE: To investigate the value of comprehensive rehabilitation therapy in 
      chronic obstructive pulmonary disease (COPD) and its effect on improvement in 
      patients' inflammation. METHODS: A total of 174 patients with acute COPD 
      exacerbation in the Affiliated Hospital of Hebei University in China from March 
      2020 to January 2022 were selected as research subjects. They were divided into 
      control, acute and stable groups according to the random number table method 
      (n=58 in each group). The control group was given conventional treatment; the 
      acute group started comprehensive rehabilitation treatment in the acute phase; in 
      the stable group, comprehensive rehabilitation treatment was initiated in the 
      stable period after the condition was stabilized with conventional treatment. 
      Tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP), 
      interleukin-6 (IL-6) and pulmonary function were measured before and after 
      treatment, with the forced expiratory volume in 1 second (FEV1), forced 
      expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio, and peak 
      expiratory flow rate (PEF). A 6-min walk test (6MWD) was performed on the 
      patient, and the ability to perform activities of daily living (ADL), self-rating 
      anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess 
      patients' ability to perform ADL and psychology. Finally, the incidence of 
      adverse events (AEs) in patients was recorded and a quality of life (QoL) survey 
      was completed. RESULTS: The 6MWD test, ADL, FEV1, FEV1/FVC and PEF were elevated 
      in the acute and stable groups compared with the control group, whereas shortness 
      of breath, TNF-alpha, hs-CRP and IL-6 were decreased (P < .05). SAS and SDS scores 
      were reduced in the acute and stable groups after treatment (P < .05), while 
      there was no change in the control group (P > .05). In addition, QoL was higher 
      in the acute and stable groups (P < .05). The improvement of all indicators in 
      the acute group was better than in the stable group (P < .05). CONCLUSION: 
      Comprehensive rehabilitation therapy can improve the exercise capacity and lung 
      function of patients with COPD, reduce inflammation, and improve patients' 
      negative psychology.
FAU - Li, Zheng
AU  - Li Z
FAU - Yan, Xuesong
AU  - Yan X
FAU - Liu, Jin
AU  - Liu J
FAU - Feng, Xin
AU  - Feng X
FAU - Li, Xiangyun
AU  - Li X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - C-Reactive Protein/metabolism
MH  - Activities of Daily Living
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Forced Expiratory Volume
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Inflammation
EDAT- 2023/03/19 06:00
MHDA- 2023/05/12 07:06
CRDT- 2023/03/18 15:52
PHST- 2023/05/12 07:06 [medline]
PHST- 2023/03/19 06:00 [pubmed]
PHST- 2023/03/18 15:52 [entrez]
AID - AT8005 [pii]
PST - ppublish
SO  - Altern Ther Health Med. 2023 May;29(4):170-176.