PMID- 36933746
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230508
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 877
DP  - 2023 Jun 15
TI  - How does habitat influence metabolism? Clues from biomarker response and 
      contaminant profile in Tursiops truncatus (Montagu, 1821) subspecies living in 
      parapatry.
PG  - 162900
LID - S0048-9697(23)01516-4 [pii]
LID - 10.1016/j.scitotenv.2023.162900 [doi]
AB  - In western South America (WSA) two subspecies of bottlenose dolphin are 
      recognized: Tursiops truncatus gephyreus, predominantly found in estuaries and 
      river mouths, and Tursiops truncatus truncatus, occurring along the continental 
      shelf. Despite a partial spatial overlap, both subspecies are considered to 
      occupy different habitats and ecological niches. In the present study, chemical 
      analyzes as well as biochemical and molecular biomarkers were used to investigate 
      the influence of niche partitioning over metabolic pathways associated with the 
      detoxification of persistent organic pollutants (POPs), antioxidant metabolism, 
      immune activity and lipid metabolism in Tursiops truncatus subspecies living in 
      parapatry. Overall, the profile and levels of bioaccumulated PCBs, pesticides and 
      PBDEs were similar between groups, with a greater variety of pesticides, such as 
      gamma-HCHs, heptachlor, oxychlordane and o,p'DDT, detected in T. truncatus gephyreus. 
      Multivariate analysis of variance (MANOVA) and non-metric multidimensional 
      scaling (NMDS) results indicated that glutathione reductase (GR) and superoxide 
      dismutase (SOD) enzymatic activities were higher in coastal dolphins, as were the 
      mRNA levels of metallothionein 2A (MT2A), interleukin-1alpha (IL-1alpha), ceramide 
      synthase 3 (CERS3) and fatty acid elongase (ELOVL4). In parallel, mRNA levels of 
      fatty acid synthase complex 1 (FASN 1) were higher in oceanic dolphins. These 
      findings suggest that, due to their occurrence in coastal habitats, T. truncatus 
      gephyreus is more exposed to environmental pollutants and pathogenic 
      microorganisms. Likewise, niche partitioning may influence lipid biosynthesis, 
      possibly due to differences on feeding habits, reflecting in an enhanced long 
      chain ceramides biosynthesis in T. truncatus gephyreus. Collectively, these data 
      reinforce the need to address habitat specificities in conservation efforts, 
      since distinct groups can be facing different anthropogenic pressures in WSA.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Righetti, Barbara P H
AU  - Righetti BPH
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil. Electronic address: ba.righetti@gmail.com.
FAU - Mattos, Jaco J
AU  - Mattos JJ
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Manaut, Luiza R
AU  - Manaut LR
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - da Silva, Josilene
AU  - da Silva J
AD  - Laboratorio de Quimica Organica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Lourenco, Rafael A
AU  - Lourenco RA
AD  - Laboratorio de Quimica Organica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Fruet, P
AU  - Fruet P
AD  - Museu Oceanografico "Prof. Eliezer de C. Rios"/Laboratorio de Ecologia e 
      Conservacao da Megafauna Marinha - Ecomega, Universidade Federal do Rio Grande - 
      FURG, Rio Grande, RS, Brazil.
FAU - Bainy, Afonso C D
AU  - Bainy ACD
AD  - Laboratorio de Biomarcadores de Contaminacao Aquatica e Imunoquimica, 
      Departamento de Bioquimica, Universidade Federal de Santa Catarina, 
      Florianopolis, Brazil.
FAU - Luchmann, Karim H
AU  - Luchmann KH
AD  - Departamento de Educacao Cientifica e Tecnologica, Universidade do Estado de 
      Santa Catarina, Florianopolis, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20230317
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (Pesticides)
SB  - IM
MH  - Animals
MH  - Environmental Monitoring
MH  - *Bottle-Nosed Dolphin/metabolism
MH  - *Water Pollutants, Chemical/analysis
MH  - *Pesticides/analysis
MH  - Ecosystem
OTO - NOTNLM
OT  - Antioxidant activity
OT  - Bottlenose dolphins
OT  - Lipid metabolism
OT  - Xenobiotics
COIS- Declaration of competing interest No competing interests declared.
EDAT- 2023/03/19 06:00
MHDA- 2023/05/08 06:41
CRDT- 2023/03/18 20:30
PHST- 2022/12/06 00:00 [received]
PHST- 2023/03/01 00:00 [revised]
PHST- 2023/03/12 00:00 [accepted]
PHST- 2023/05/08 06:41 [medline]
PHST- 2023/03/19 06:00 [pubmed]
PHST- 2023/03/18 20:30 [entrez]
AID - S0048-9697(23)01516-4 [pii]
AID - 10.1016/j.scitotenv.2023.162900 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jun 15;877:162900. doi: 10.1016/j.scitotenv.2023.162900. 
      Epub 2023 Mar 17.