PMID- 36933751 OWN - NLM STAT- MEDLINE DCOM- 20230626 LR - 20231124 IS - 1097-6809 (Electronic) IS - 0741-5214 (Linking) VI - 78 IP - 1 DP - 2023 Jul TI - Impact of ambulatory status change on survival in patients with chronic limb-threatening ischemia undergoing infrainguinal surgical or endovascular revascularization. PG - 193-200.e2 LID - S0741-5214(23)00469-X [pii] LID - 10.1016/j.jvs.2023.03.024 [doi] AB - OBJECTIVE: This study aimed to evaluate the influence of change in ambulatory status on the prognosis of patients with chronic limb-threatening ischemia (CLTI) undergoing infrainguinal bypass surgery or endovascular therapy (EVT). METHODS: We retrospectively analyzed data from two vascular centers for patients who underwent revascularization for CLTI between 2015 and 2020. The primary endpoint was overall survival (OS), and the secondary endpoints were changes in ambulatory status and postoperative complications. RESULTS: Throughout the study, 377 patients and 508 limbs were analyzed. In the preoperative nonambulation cohort, the average body mass index (BMI) was lower in the postoperative nonambulatory group than in the postoperative ambulatory group (P < .01). The percentage of cerebrovascular disease (CVD) was higher in the postoperative nonambulatory group than in the postoperative ambulatory group (P = .01). In the preoperative ambulation cohort, the average controlling nutritional status (CONUT) score was higher in the postoperative nonambulatory group than in the postoperative ambulatory group (P < .01). There was no difference in the bypass percentage and the EVT in the preoperative nonambulation (P = .32) and ambulation (P = .70) cohorts. According to the change in ambulatory status before and after revascularization, the 1-year OS rates were 86.8% in the ambulatory --> ambulatory group, 81.1% in the nonambulatory --> ambulatory group, 54.7% in the nonambulatory --> nonambulatory group, and 23.9% in the ambulatory --> nonambulatory group (P < .01). On multivariate analysis, increased age (P = .04), higher Wound, Ischemia, and foot Infection stage (P = .02), and increased CONUT score (P < .01) were independent risk factors for the decline in ambulatory status in patients with preoperative ambulation. In patients with preoperative nonambulation, increased BMI (P < .01) and absence of CVD (P = .04) were independent factors related to the improved ambulatory status. The percentages of postoperative complications were 31.0% and 17.0% in the preoperative nonambulation and the preoperative ambulation in the overall cohort (P < .01). Preoperative nonambulatory status (P < .01), CONUT score (P < .01), and bypass surgery (P < .01) were risk factors for postoperative complications. CONCLUSIONS: Improved ambulatory status is associated with better OS in patients with preoperative nonambulatory status after infrainguinal revascularization for CLTI. Although patients with preoperative nonambulatory status have a risk of postoperative complication, some may benefit from revascularization if they have no factors such as low BMI and CVD, improving their ambulatory status. CI - Copyright (c) 2023 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved. FAU - Morisaki, Koichi AU - Morisaki K AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: morisaki.koichi.533@m.kyushu-u.ac.jp. FAU - Guntani, Atsushi AU - Guntani A AD - Department of Vascular Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan. FAU - Kinoshita, Go AU - Kinoshita G AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Kawanami, Shogo AU - Kawanami S AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Yamashita, Sho AU - Yamashita S AD - Department of Vascular Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan. FAU - Matsubara, Yutaka AU - Matsubara Y AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Furuyama, Tadashi AU - Furuyama T AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Mii, Shinsuke AU - Mii S AD - Department of Vascular Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan. FAU - Komori, Kimihiro AU - Komori K AD - Department of Vascular Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan. FAU - Yoshizumi, Tomoharu AU - Yoshizumi T AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. LA - eng PT - Journal Article DEP - 20230316 PL - United States TA - J Vasc Surg JT - Journal of vascular surgery JID - 8407742 SB - IM MH - Humans MH - Chronic Limb-Threatening Ischemia MH - Retrospective Studies MH - *Peripheral Arterial Disease/diagnostic imaging/surgery MH - Limb Salvage/adverse effects MH - Treatment Outcome MH - Risk Factors MH - Ischemia/diagnostic imaging/surgery MH - Postoperative Complications/etiology MH - *Endovascular Procedures/adverse effects MH - Chronic Disease OTO - NOTNLM OT - Chronic limb-threatening ischemia (CLTI) OT - Decline in ambulatory status OT - Improved ambulatory status OT - Infrainguinal revascularization OT - Overall survival OT - Perioperative complications. EDAT- 2023/03/19 06:00 MHDA- 2023/06/26 06:41 CRDT- 2023/03/18 20:30 PHST- 2023/01/29 00:00 [received] PHST- 2023/03/05 00:00 [revised] PHST- 2023/03/07 00:00 [accepted] PHST- 2023/06/26 06:41 [medline] PHST- 2023/03/19 06:00 [pubmed] PHST- 2023/03/18 20:30 [entrez] AID - S0741-5214(23)00469-X [pii] AID - 10.1016/j.jvs.2023.03.024 [doi] PST - ppublish SO - J Vasc Surg. 2023 Jul;78(1):193-200.e2. doi: 10.1016/j.jvs.2023.03.024. Epub 2023 Mar 16.