PMID- 36934048
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230520
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 34
IP  - 5
DP  - 2023 May
TI  - Regulatory effect of orexin system on various diseases through mTOR signaling 
      pathway.
PG  - 292-302
LID - S1043-2760(23)00051-6 [pii]
LID - 10.1016/j.tem.2023.02.008 [doi]
AB  - Orexin (OX)A and OXB are a pair of neuropeptides secreted by orexin-producing 
      neurons in the lateral hypothalamus. The orexin system can regulate many 
      physiological processes through these two receptor pathways, such as feeding 
      behavior, sleep/wake state, energy homeostasis, reward, and the coordination of 
      emotion. Mammalian target of rapamycin (mTOR) can coordinate upstream signals 
      with downstream effectors, thereby regulating fundamental cellular processes and 
      also plays an essential role in the signaling network downstream of the orexin 
      system. In turn, the orexin system can activate mTOR. Here, we review the 
      association of the orexin system with the mTOR signaling pathway mainly by 
      discussing that drugs in various diseases exert their effects on the orexin 
      system, indirectly affecting the mTOR signaling pathway.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Song, Ying
AU  - Song Y
AD  - Department of Pharmacology, Zhejiang University of Technology, Hangzhou, 
      Zhejiang, China. Electronic address: songying@zjut.edu.cn.
FAU - Wang, Beibei
AU  - Wang B
AD  - Department of Pharmacology, Zhejiang University of Technology, Hangzhou, 
      Zhejiang, China.
FAU - Wang, Wenjun
AU  - Wang W
AD  - Department of Pharmacology, Zhejiang University of Technology, Hangzhou, 
      Zhejiang, China.
FAU - Shi, Qiwen
AU  - Shi Q
AD  - Department of Pharmacology, Zhejiang University of Technology, Hangzhou, 
      Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230316
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Orexins)
RN  - 0 (Orexin Receptors)
RN  - 0 (Neuropeptides)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Orexins
MH  - Orexin Receptors
MH  - *Neuropeptides/metabolism
MH  - Signal Transduction/physiology
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Mammals/metabolism
OTO - NOTNLM
OT  - cerebral ischemia-reperfusion injury
OT  - mammalian target of rapamycin
OT  - orexin
OT  - orexinergic receptor
COIS- Declaration of interests No interests are declared.
EDAT- 2023/03/19 06:00
MHDA- 2023/04/14 06:41
CRDT- 2023/03/18 23:08
PHST- 2023/01/12 00:00 [received]
PHST- 2023/02/19 00:00 [revised]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/04/14 06:41 [medline]
PHST- 2023/03/19 06:00 [pubmed]
PHST- 2023/03/18 23:08 [entrez]
AID - S1043-2760(23)00051-6 [pii]
AID - 10.1016/j.tem.2023.02.008 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2023 May;34(5):292-302. doi: 10.1016/j.tem.2023.02.008. 
      Epub 2023 Mar 16.