PMID- 36934422
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20231116
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 67
IP  - 12
DP  - 2023 Jun
TI  - The Hypoglycemic Activities and Underlying Mechanisms of Two Saponins-Rich 
      Components from Fried Ziziphus jujuba Mill. Kernel.
PG  - e2200364
LID - 10.1002/mnfr.202200364 [doi]
AB  - SCOPE: Dried Ziziphus jujuba Mill. kernel is a potential natural source of 
      nutraceutical and therapeutic agents in China. Recent researches have shown that 
      the saponins of dried Z. jujuba Mill. kernel (SZJs: SZJ-1 and SZJ-2) have various 
      biological effects. However, the hypoglycemic activities and underlying 
      mechanisms of SZJs remain obscure. METHOD AND RESULTS: In the current study, two 
      saponins SZJ-1 and SZJ-2 mainly composed of betulinic acid, spinosin, jujuboside 
      A, and jujuboside B are extracted and is olated from dried Z. jujuba Mill. 
      kernel. The SZJ-1 and SZJ-2 could significantly inhibit the activities of 
      digestion enzymes alpha-glucosidase and alpha-amylases. The hypoglycemic ability of SZJ-1 
      and SZJ-2 is further investigated and the results show that SZJ-1 and SZJ-2 can 
      improve the hyperglycemic by increasing the glucose consumption, improving the 
      superoxide dismutase (SOD), hexokinase (HK), pyruvate kinase (PK) activities, and 
      decrease the MDA content of insulin resistant HepG2 cells. Furthermore, SZJ-1 and 
      SZJ-2 can activate the phosphorated adenosine 5'-monophosphate (AMP)-activated 
      protein kinase alpha (p-AMPK), phosphoinositide 3-kinase p110alpha (PI3K-p110alpha), and 
      phosphorated glycogen synthase kinase-3beta (Ser9) (p-GSK3beta). CONCLUSION: These 
      results indicating that the SZJ-1 and SZJ-2 might improve the insulin resistant 
      symptoms by improving the energy metabolic level and increasing the glycogen 
      synthase activity of HepG2 cells.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Li, Yi-Meng
AU  - Li YM
AD  - School of Food Science and Engineering, South China University of Technology, 
      Guangzhou, 510640, China.
FAU - Hao, Ke-Xin
AU  - Hao KX
AD  - School of Food Science and Engineering, South China University of Technology, 
      Guangzhou, 510640, China.
FAU - Xie, Hong
AU  - Xie H
AD  - School of Food Science and Engineering, South China University of Technology, 
      Guangzhou, 510640, China.
FAU - Jiang, Jian-Guo
AU  - Jiang JG
AUID- ORCID: 0000-0002-3361-6149
AD  - School of Food Science and Engineering, South China University of Technology, 
      Guangzhou, 510640, China.
AD  - Guangxi Academy of Sciences, Guangxi Mangrove Research Center, Guangxi Key Lab of 
      Mangrove Conservation and Utilization, Beihai, 536000, China.
LA  - eng
PT  - Journal Article
DEP - 20230514
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Plant Extracts)
RN  - 0 (Hypoglycemic Agents)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - 0 (Saponins)
RN  - 0 (Insulins)
SB  - IM
MH  - Plant Extracts/pharmacology
MH  - *Ziziphus
MH  - Hypoglycemic Agents/pharmacology
MH  - Phosphatidylinositol 3-Kinases
MH  - *Saponins/pharmacology
MH  - *Insulins
OTO - NOTNLM
OT  - Ziziphus jujuba Mill. kernel
OT  - chemical composition
OT  - hypoglycemic activities
OT  - saponins
EDAT- 2023/03/20 06:00
MHDA- 2023/06/26 06:41
CRDT- 2023/03/19 14:14
PHST- 2023/01/15 00:00 [revised]
PHST- 2022/06/05 00:00 [received]
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/03/20 06:00 [pubmed]
PHST- 2023/03/19 14:14 [entrez]
AID - 10.1002/mnfr.202200364 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2023 Jun;67(12):e2200364. doi: 10.1002/mnfr.202200364. Epub 
      2023 May 14.