PMID- 36934863
OWN - NLM
STAT- MEDLINE
DCOM- 20230417
LR  - 20230417
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 226
DP  - 2023 Jun 1
TI  - Exposure to household dust, allergens, and endotoxin and allergy-related outcomes 
      alternation in the general U.S. population.
PG  - 115713
LID - S0013-9351(23)00505-4 [pii]
LID - 10.1016/j.envres.2023.115713 [doi]
AB  - It has been widely reported that the general population was at an increased risk 
      of allergy diseases, which probably be related with household allergens exposure. 
      However, the difference of local and systemic allergic reactions exposure to 
      allergens has not been reported in the general population previously. The data of 
      1094 U.S. adults from the National Health and Nutrition Examination Survey 
      (NHANES) 2005-2006 data bank were analyzed. Dust, allergens (Bia g 1, Bia g 2, 
      Can f 1, Feld 1, Derp 1, Mus m 1, Rat n 1, Alternaria alternate, and Aspergillus 
      fumigatus), and endotoxin, were measured to estimate sensitizing source exposure. 
      And allergy-related outcomes indicators including hay fever, sneezing, allergic 
      rhinitis (AR), immunoglobulin E (IgE), and allergic sensitization, were evaluzted 
      to estimate local and systemic allergic reactions. Multiple linear regression and 
      logistic regression models were used to examine the associations of sensitizer 
      and allergy-related outcomes. The mean or median concentration of dust and 
      endotoxin were 0.66 g and 12.98 EU/mg dust. The Derp 1, Mus m 1, Rat n 1, 
      Alternaria alternate, and Aspergillus fumigatus were the main allergens in the 
      dust, with the concentrations of 30.66 ng/g dust, 30.73 ng/g dust, 5.94 ng/g 
      dust, 5.20 ng/g dust, and 207.68 mug/g dust, respectively. The prevalence of AR 
      was 34.2% among the general population. After controlling for sociodemographic 
      factors, we found that the allergens, such as Can f 1 and Feld 1, were positively 
      associated with AR. The prevalence of allergic sensitization was about 20%. Dust 
      and endotoxin were found positively associated with allergic sensitization, while 
      Bia g 2, Rat n 1, Alternaria alternate, and Aspergillus fumigatus were inversely 
      associated with that. Dust and endotoxin probably be associated with higher risk 
      of local allergic reactions, while some allergens, such as Bia g 2, Rat n 1, 
      Alternaria alternate, and Aspergillus fumigatus probably be associated with lower 
      risk of systemic allergic reactions.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Yan, Tenglong
AU  - Yan T
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing, 
      100093, China.
FAU - Song, Xin
AU  - Song X
AD  - School of Public Health and the Beijing Key Laboratory of Environmental 
      Toxicology, Capital Medical University, Beijing, 100069, China.
FAU - Ding, Xiaowen
AU  - Ding X
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing, 
      100093, China.
FAU - Liu, Xiaodong
AU  - Liu X
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing, 
      100093, China.
FAU - Lan, Tian
AU  - Lan T
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing, 
      100093, China.
FAU - Chen, Tian
AU  - Chen T
AD  - School of Public Health and the Beijing Key Laboratory of Environmental 
      Toxicology, Capital Medical University, Beijing, 100069, China.
FAU - Wang, Minghui
AU  - Wang M
AD  - Department of Neurology, Sanbo Brain Hospital, Capital Medical University, 
      Beijing, 100093, China. Electronic address: wangmh0503@163.com.
FAU - Wang, Mengyang
AU  - Wang M
AD  - Department of Neurology, Sanbo Brain Hospital, Capital Medical University, 
      Beijing, 100093, China. Electronic address: mengyangwang@ccmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230318
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Dust)
RN  - 0 (Endotoxins)
RN  - 0 (Allergens)
SB  - IM
MH  - Mice
MH  - Rats
MH  - Animals
MH  - Humans
MH  - Dust
MH  - Nutrition Surveys
MH  - Endotoxins
MH  - Allergens
MH  - *Rhinitis, Allergic, Seasonal/epidemiology
MH  - *Rhinitis, Allergic/epidemiology
MH  - Aspergillus fumigatus
OTO - NOTNLM
OT  - Allergens
OT  - Allergic rhinitis (AR)
OT  - Allergic sensitization
OT  - Local allergic reactions
OT  - Systemic allergic reactions
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/03/20 06:00
MHDA- 2023/04/17 06:41
CRDT- 2023/03/19 20:28
PHST- 2023/02/20 00:00 [received]
PHST- 2023/03/13 00:00 [revised]
PHST- 2023/03/16 00:00 [accepted]
PHST- 2023/04/17 06:41 [medline]
PHST- 2023/03/20 06:00 [pubmed]
PHST- 2023/03/19 20:28 [entrez]
AID - S0013-9351(23)00505-4 [pii]
AID - 10.1016/j.envres.2023.115713 [doi]
PST - ppublish
SO  - Environ Res. 2023 Jun 1;226:115713. doi: 10.1016/j.envres.2023.115713. Epub 2023 
      Mar 18.