PMID- 36935039
OWN - NLM
STAT- MEDLINE
DCOM- 20230609
LR  - 20230609
IS  - 1578-2190 (Electronic)
IS  - 0001-7310 (Linking)
VI  - 114
IP  - 6
DP  - 2023 Jun
TI  - BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.
PG  - 479-487
LID - S0001-7310(23)00181-3 [pii]
LID - 10.1016/j.ad.2023.03.001 [doi]
AB  - BACKGROUND: In recent years, remarkable improvements in our understanding of 
      atopic dermatitis (AD) have revolutionized treatment perspectives, but access to 
      reliable data from clinical practice is essential. MATERIALS AND METHOD: The 
      Spanish Atopic Dermatitis Registry, BIOBADATOP, is a prospective, multicenter 
      database that collects information on patients of all ages with AD requiring 
      systemic therapy with conventional or novel drugs. We analyzed the registry to 
      describe patient characteristics, diagnoses, treatments, and adverse events 
      (AEs). RESULTS: We studied data entries for 258 patients who had received 347 
      systemic treatments for AD. Treatment was discontinued in 29.4% of cases, mostly 
      due to a lack of effectiveness (in 10.7% of cases). A total of 132 AEs were 
      described during follow-up. Eighty-six AEs (65%) were linked to a systemic 
      treatment, most commonly dupilumab (39AEs) and cyclosporine (38AEs). The most 
      common AEs were conjunctivitis (11patients), headache (6), hypertrichosis (5), 
      and nausea (4). There was 1severe AE (acute mastoiditis) associated with 
      cyclosporine. CONCLUSIONS: Initial findings on AEs from the Spanish BIOBADATOP 
      registry are limited by short follow-up times precluding comparisons or 
      calculation of crude and adjusted incidence rates. At the time of our analysis, 
      no severe AEs had been reported for novel systemic therapies. BIOBADATOP will 
      help answer questions on the effectiveness and safety of conventional and novel 
      systemic therapies in AD.
CI  - Copyright (c) 2023 AEDV. Publicado por Elsevier Espana, S.L.U. All rights reserved.
FAU - Munera-Campos, M
AU  - Munera-Campos M
AD  - Servicio de Dermatologia, Hospital Universitari Germans Trias i Pujol, 
      Universitat Autonoma de Barcelona; Germans Trias i Pujol Research Institute 
      (IGTP), Badalona, Barcelona, Espana. Electronic address: muneracampos@gmail.com.
FAU - Chicharro, P
AU  - Chicharro P
AD  - Servicio de Dermatologia, Hospital Universitario de La Princesa, Madrid, Espana.
FAU - Gonzalez Quesada, A
AU  - Gonzalez Quesada A
AD  - Servicio de Dermatologia, Hospital Universitario de Gran Canaria Doctor Negrin, 
      Las Palmas de Gran Canaria, Espana.
FAU - Florez Menendez, A
AU  - Florez Menendez A
AD  - Servicio de Dermatologia, Complejo Hospitalario Universitario de Pontevedra, 
      Pontevedra, Espana.
FAU - de la Cueva Dobao, P
AU  - de la Cueva Dobao P
AD  - Servicio de Dermatologia, Hospital Universitario Infanta Leonor, Madrid, Espana.
FAU - Gimenez Arnau, A M
AU  - Gimenez Arnau AM
AD  - Servicio de Dermatologia, Hospital del Mar-Parc de Salut Mar, Barcelona, Espana.
FAU - Gilaberte Calzada, Y
AU  - Gilaberte Calzada Y
AD  - Servicio de Dermatologia, Hospital Universitario Miguel Servet, Zaragoza, Espana.
FAU - Rodriguez Serna, M
AU  - Rodriguez Serna M
AD  - Servicio de Dermatologia, Hospital Universitario y Politecnico la Fe, Valencia, 
      Espana.
FAU - Montero-Vilchez, T
AU  - Montero-Vilchez T
AD  - Servicio de Dermatologia, Hospital Universitario Virgen de las Nieves. Instituto 
      de Investigacion Biosanitaria ibs.GRANADA, Granada, Espana.
FAU - Silvestre, J F
AU  - Silvestre JF
AD  - Servicio de Dermatologia, Hospital General Universitario Dr Balmis, ISABIAL, 
      Alicante, Espana.
FAU - Elosua-Gonzalez, M
AU  - Elosua-Gonzalez M
AD  - Servicio de Dermatologia, Hospital Universitario Puerta de Hierro Majadahonda, 
      Madrid, Espana.
FAU - Del Alcazar, E
AU  - Del Alcazar E
AD  - Servicio de Dermatologia, Hospital Universitari Germans Trias i Pujol, 
      Universitat Autonoma de Barcelona; Germans Trias i Pujol Research Institute 
      (IGTP), Badalona, Barcelona, Espana.
FAU - Santamaria, C
AU  - Santamaria C
AD  - Servicio de Dermatologia, Hospital Universitario de La Princesa, Madrid, Espana.
FAU - Sanchez-Perez, J
AU  - Sanchez-Perez J
AD  - Servicio de Dermatologia, Hospital Universitario de La Princesa, Madrid, Espana.
FAU - Carretero Hernandez, G
AU  - Carretero Hernandez G
AD  - Servicio de Dermatologia, Hospital Universitario de Gran Canaria Doctor Negrin, 
      Las Palmas de Gran Canaria, Espana.
FAU - Batalla, A
AU  - Batalla A
AD  - Servicio de Dermatologia, Complejo Hospitalario Universitario de Pontevedra, 
      Pontevedra, Espana.
FAU - Jin Suh Oh, H
AU  - Jin Suh Oh H
AD  - Servicio de Dermatologia, Complejo Hospitalario Universitario de Pontevedra, 
      Pontevedra, Espana.
FAU - Mauleon Fernandez, C
AU  - Mauleon Fernandez C
AD  - Servicio de Dermatologia, Hospital Universitario Infanta Leonor, Madrid, Espana.
FAU - Curto Barredo, L
AU  - Curto Barredo L
AD  - Servicio de Dermatologia, Hospital del Mar-Parc de Salut Mar, Barcelona, Espana.
FAU - Bertolin-Colilla, M
AU  - Bertolin-Colilla M
AD  - Servicio de Dermatologia, Hospital del Mar-Parc de Salut Mar, Barcelona, Espana.
FAU - Navarro Bielsa, A
AU  - Navarro Bielsa A
AD  - Servicio de Dermatologia, Hospital Universitario Miguel Servet, Zaragoza, Espana.
FAU - Ballano Ruiz, A
AU  - Ballano Ruiz A
AD  - Servicio de Dermatologia, Hospital Universitario Miguel Servet, Zaragoza, Espana.
FAU - Botella Estrada, R
AU  - Botella Estrada R
AD  - Servicio de Dermatologia, Hospital Universitario y Politecnico la Fe, Valencia, 
      Espana.
FAU - Arias Santiago, S
AU  - Arias Santiago S
AD  - Servicio de Dermatologia, Hospital Universitario Virgen de las Nieves. Instituto 
      de Investigacion Biosanitaria ibs.GRANADA, Granada, Espana.
FAU - Betlloch, I
AU  - Betlloch I
AD  - Servicio de Dermatologia, Hospital General Universitario Dr Balmis, ISABIAL, 
      Alicante, Espana.
FAU - Roustan Gullon, G
AU  - Roustan Gullon G
AD  - Servicio de Dermatologia, Hospital Universitario Puerta de Hierro Majadahonda, 
      Madrid, Espana.
FAU - Rosell Diaz, A
AU  - Rosell Diaz A
AD  - Servicio de Dermatologia, Hospital Universitario Puerta de Hierro Majadahonda, 
      Madrid, Espana.
FAU - Descalzo, M A
AU  - Descalzo MA
AD  - Unidad de Investigacion, Fundacion Piel Sana AEDV, Madrid, Espana.
FAU - Garcia-Doval, I
AU  - Garcia-Doval I
AD  - Unidad de Investigacion, Fundacion Piel Sana AEDV, Madrid, Espana; Servicio de 
      Dermatologia, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, 
      Espana.
FAU - Carrascosa, J M
AU  - Carrascosa JM
AD  - Servicio de Dermatologia, Hospital Universitari Germans Trias i Pujol, 
      Universitat Autonoma de Barcelona; Germans Trias i Pujol Research Institute 
      (IGTP), Badalona, Barcelona, Espana.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Multicenter Study
TT  - BIOBADATOP: Registro Espanol de Dermatitis Atopica. Descripcion y primeros 
      resultados.
DEP - 20230317
PL  - Spain
TA  - Actas Dermosifiliogr
JT  - Actas dermo-sifiliograficas
JID - 0373062
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Humans
MH  - *Dermatitis, Atopic/drug therapy/epidemiology
MH  - Prospective Studies
MH  - Cyclosporine/therapeutic use
MH  - Administration, Cutaneous
MH  - Registries
MH  - Treatment Outcome
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Acontecimientos adversos
OT  - Adverse events
OT  - Atopic dermatitis
OT  - Biologics
OT  - Biologicos
OT  - Dermatitis atopica
OT  - Inhibidores de JAK
OT  - JAK inhibitors
OT  - Registries
OT  - Registro prospectivo
OT  - Tratamientos
OT  - Treatments
EDAT- 2023/03/20 06:00
MHDA- 2023/06/09 06:41
CRDT- 2023/03/19 20:31
PHST- 2023/03/06 00:00 [received]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/06/09 06:41 [medline]
PHST- 2023/03/20 06:00 [pubmed]
PHST- 2023/03/19 20:31 [entrez]
AID - S0001-7310(23)00181-3 [pii]
AID - 10.1016/j.ad.2023.03.001 [doi]
PST - ppublish
SO  - Actas Dermosifiliogr. 2023 Jun;114(6):479-487. doi: 10.1016/j.ad.2023.03.001. 
      Epub 2023 Mar 17.