PMID- 36935544
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230414
IS  - 2586-6060 (Electronic)
IS  - 2586-6052 (Print)
IS  - 2586-6052 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Feb
TI  - Successful treatment of propofol-related infusion syndrome in critically ill 
      patient receiving low-dose propofol infusion: a case report.
PG  - 144-148
LID - 10.4266/acc.2021.00829 [doi]
AB  - Propofol is widely used to sedate agitated patients in intensive care units. 
      However, it can cause a rare but fatal complication, propofol-related infusion 
      syndrome (PRIS). The pathophysiology of PRIS is not clear, and there is no 
      definitive diagnosis and treatment. We report a successfully treated case of PRIS 
      in a critically ill patient receiving low-dose propofol infusion. A 59-year-old 
      male patient complaining of sudden chest pain repeatedly collapsed in an 
      ambulance and the emergency room, and veno-arterial extracorporeal membrane 
      oxygenation was delivered. He was diagnosed with a total occluded left anterior 
      descending coronary artery in coronary angiography. On day 20, he showed 
      arrhythmia, increased creatinine kinase (CK), and increased CK-MB and troponin I, 
      accompanied by unstable hemodynamic status despite high-dose vasopressors. He was 
      administered propofol for 20 days at an average dose of 1.3 mg/kg/hr owing to 
      issues with agitation and ventilator synchrony. We strongly suspected PRIS and 
      immediately discontinued propofol infusion, and he was successfully treated with 
      aggressive supportive care. PRIS can occur in patients administered propofol for 
      a prolonged period at low doses. Thus, clinicians should use propofol with 
      caution for PRIS and change to alternative sedatives for long-term sedation.
FAU - Park, Nahyeon
AU  - Park N
AD  - Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
FAU - Ha, Tae Sun
AU  - Ha TS
AD  - Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
LA  - eng
PT  - Case Reports
DEP - 20211126
PL  - Korea (South)
TA  - Acute Crit Care
JT  - Acute and critical care
JID - 101726905
PMC - PMC10030236
OTO - NOTNLM
OT  - Busan and Department of Anesthesia and Pain Medicine
OT  - Department of Anesthesia and Pain Medicine
OT  - Korea
OT  - Medical Research Institute
OT  - Pusan National University Hospital
OT  - Pusan National University School of Medicine
OT  - Yangsan
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/03/21 06:00
MHDA- 2023/03/21 06:01
PMCR- 2023/02/01
CRDT- 2023/03/20 00:26
PHST- 2021/06/21 00:00 [received]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2023/03/20 00:26 [entrez]
PHST- 2023/03/21 06:00 [pubmed]
PHST- 2023/03/21 06:01 [medline]
PHST- 2023/02/01 00:00 [pmc-release]
AID - acc.2021.00829 [pii]
AID - acc-2021-00829 [pii]
AID - 10.4266/acc.2021.00829 [doi]
PST - ppublish
SO  - Acute Crit Care. 2023 Feb;38(1):144-148. doi: 10.4266/acc.2021.00829. Epub 2021 
      Nov 26.