PMID- 36938866
OWN - NLM
STAT- MEDLINE
DCOM- 20230809
LR  - 20230909
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 12
IP  - 20
DP  - 2023 Aug
TI  - Sequential Dual-Biofactor Release from the Scaffold of Mesoporous HA Microspheres 
      and PLGA Matrix for Boosting Endogenous Bone Regeneration.
PG  - e2300624
LID - 10.1002/adhm.202300624 [doi]
AB  - The combined design of scaffold structure and multi-biological factors is a 
      prominent strategy to promote bone regeneration. Herein, a composite scaffold of 
      mesoporous hydroxyapatite (HA) microspheres loaded with the bone morphogenetic 
      protein-2 (BMP-2) and a poly(DL-lactic-co-glycolic acid) (PLGA) matrix is 
      constructed by 3D printing. Furthermore, the chemokine stromal cell-derived 
      factor-1alpha (SDF-1alpha) is adsorbed on a scaffold surface to achieve the sequential 
      release of the dual-biofactors. The results indicate that the rapid release of 
      SDF-1alpha chemokine on the scaffold surface effectively recruits bone marrow-derived 
      mesenchymal stem cells (BMSCs) to the target defect area, whereas the long-term 
      sustained release of BMP-2 from the HA microspheres in the degradable PLGA matrix 
      successfully triggers the osteogenic differentiation in the recruited BMSCs, 
      significantly promoting bone regeneration and reconstruction. In addition, these 
      structures/biofactors specially combining scaffold exhibit significantly better 
      biological performance than that of other combined scaffolds, including the bare 
      HA/PLGA scaffold, the scaffold loaded with SDF-1alpha or BMP-2 biofactor alone, and 
      the scaffold with surface SDF-1alpha and BMP-2 dual-biofactors. The utilization of 
      mesoporous HA, the assembly method, and sequential release of the two biofactors 
      in the 3D printed composite scaffold present a new method for future design of 
      high-performance bone repairing scaffolds.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Wei, Jiawei
AU  - Wei J
AUID- ORCID: 0000-0002-1605-6581
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Xia, Xue
AU  - Xia X
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Xiao, Shiqi
AU  - Xiao S
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Jin, Shue
AU  - Jin S
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Zou, Qin
AU  - Zou Q
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Zuo, Yi
AU  - Zuo Y
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Li, Yubao
AU  - Li Y
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
FAU - Li, Jidong
AU  - Li J
AUID- ORCID: 0000-0002-0483-3304
AD  - Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan 
      University, Chengdu, 610064, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230402
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 91D9GV0Z28 (Durapatite)
RN  - 0 (Chemokine CXCL12)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - *Durapatite/pharmacology/chemistry
MH  - *Osteogenesis
MH  - Microspheres
MH  - Tissue Scaffolds/chemistry
MH  - Chemokine CXCL12/pharmacology
MH  - Lactic Acid/chemistry
MH  - Bone Regeneration
OTO - NOTNLM
OT  - BMP-2 protein
OT  - SDF-1alpha chemokine
OT  - composite scaffolds
OT  - endogenous bone regeneration
OT  - mesoporous hydroxyapatite
EDAT- 2023/03/21 06:00
MHDA- 2023/08/09 06:42
CRDT- 2023/03/20 05:34
PHST- 2023/02/26 00:00 [received]
PHST- 2023/08/09 06:42 [medline]
PHST- 2023/03/21 06:00 [pubmed]
PHST- 2023/03/20 05:34 [entrez]
AID - 10.1002/adhm.202300624 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2023 Aug;12(20):e2300624. doi: 10.1002/adhm.202300624. Epub 
      2023 Apr 2.