PMID- 36939231
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20230520
IS  - 1502-7724 (Electronic)
IS  - 0281-3432 (Print)
IS  - 0281-3432 (Linking)
VI  - 41
IP  - 2
DP  - 2023 Jun
TI  - Development over time in point-of-care test use in Danish daytime and 
      out-of-hours general practice: a register-based study.
PG  - 108-115
LID - 10.1080/02813432.2023.2187667 [doi]
AB  - OBJECTIVE: To describe the development over time of the use of C-reactive protein 
      (CRP) and rapid streptococcal detection test (RADT) point-of-care tests (POCT) in 
      Danish general practice and to explore associations between patient 
      characteristics and POCT use (i.e. CRP and RADT). DESIGN AND SETTINGS: A 
      register-based study including all general practice clinic consultations in 
      daytime and out-of-hours (OOH) settings in Denmark between 2003 and 2018. 
      SUBJECTS: All citizens who had at least one clinic consultation in daytime or OOH 
      general practice within the study period. MAIN OUTCOME MEASURES: We estimated the 
      total and relative use of CRP and RADT POCTs and described the development over 
      time. Crude and adjusted proportion ratios (PRs) were calculated to explore 
      associations between patient characteristics and POCT use. RESULTS: Overall, the 
      relative use of CRP POCTs increased. At OOH, a steep increase was noticed around 
      2012. The relative use of RADT decreased. Patient age 40-59 years and existing 
      comorbidity were significantly associated with a higher use of CRP testing in 
      both settings. A significantly lower use of CRP testing was found for patients 
      with higher educational level. We found a significantly higher use of RADT 
      testing for patients aged 0-19 years and with higher household educational level, 
      whereas comorbidity was associated with a lower use of RADT testing. CONCLUSION: 
      The use of CRP POCT increased over time, whereas the use of RADT POCT decreased. 
      Perhaps the success of implementing CRP as a tool for reducing antibiotic use has 
      reached it limit. Future studies should focus on how and when POCT are used most 
      optimal.Key pointsCRP POC tests and RADT POCTs are frequently used diagnostic 
      tools in general practice, both in daytime and in the out-of-hours setting.There 
      was an increased use of CRP POCTs, particularly in out-of-hours general practice, 
      whereas the use of RADT POCTs declined between 2003 and 2018.CRP POCTs were 
      associated with age of 40-59 years and co-morbidity, while the use of RADT was 
      mostly associated with younger age.
FAU - Kjaer, Niels
AU  - Kjaer N
AD  - Research Unit for General Practice, Aarhus, Denmark.
FAU - Plejdrup Hansen, Malene
AU  - Plejdrup Hansen M
AUID- ORCID: 0000-0002-8444-1369
AD  - Center for General Practice at, Aalborg University, Aalborg, Denmark.
FAU - Schou Pedersen, Henrik
AU  - Schou Pedersen H
AUID- ORCID: 0000-0003-4826-6441
AD  - Research Unit for General Practice, Aarhus, Denmark.
FAU - Bondo Christensen, Morten
AU  - Bondo Christensen M
AUID- ORCID: 0000-0002-8342-7418
AD  - Research Unit for General Practice, Aarhus, Denmark.
AD  - Institute for Public Health, Aarhus University, Aarhus, Denmark.
FAU - Huibers, Linda
AU  - Huibers L
AUID- ORCID: 0000-0002-5048-3026
AD  - Research Unit for General Practice, Aarhus, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20230320
PL  - United States
TA  - Scand J Prim Health Care
JT  - Scandinavian journal of primary health care
JID - 8510679
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Humans
MH  - Point-of-Care Testing
MH  - *General Practice
MH  - Family Practice
MH  - C-Reactive Protein/analysis
MH  - Anti-Bacterial Agents/therapeutic use
MH  - *After-Hours Care
MH  - Denmark
PMC - PMC10193912
OTO - NOTNLM
OT  - C-reactive protein
OT  - Point-of-care testing
OT  - after-hours care
OT  - general practice
OT  - out-of-hours medical care
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2023/03/21 06:00
MHDA- 2023/05/19 06:42
PMCR- 2023/03/20
CRDT- 2023/03/20 09:04
PHST- 2023/05/19 06:42 [medline]
PHST- 2023/03/21 06:00 [pubmed]
PHST- 2023/03/20 09:04 [entrez]
PHST- 2023/03/20 00:00 [pmc-release]
AID - 2187667 [pii]
AID - 10.1080/02813432.2023.2187667 [doi]
PST - ppublish
SO  - Scand J Prim Health Care. 2023 Jun;41(2):108-115. doi: 
      10.1080/02813432.2023.2187667. Epub 2023 Mar 20.