PMID- 36939314
OWN - NLM
STAT- MEDLINE
DCOM- 20230929
LR  - 20230929
IS  - 1784-973X (Electronic)
IS  - 0001-5385 (Linking)
VI  - 78
IP  - 8
DP  - 2023 Oct
TI  - Plaque morphology and distribution in patients with and without myocardial bridge 
      - an intravascular ultrasound study.
PG  - 894-900
LID - 10.1080/00015385.2023.2187117 [doi]
AB  - BACKGROUND: Myocardial bridging (MB) is a common congenital cardiovascular 
      anomaly. There are reported associations of MB with different clinical 
      presentations like effort angina, acute coronary syndromes (ACS) and sudden 
      cardiac death. Acceleration of atherosclerosis in proximal vessel is reported in 
      patients with MB, while bridged segments are reported to be free of 
      atherosclerosis. METHODS: We assessed patients who underwent intravascular 
      ultrasound (IVUS) guided percutaneous intervention (PCI) of left anterior 
      descending (LAD) artery. Plaque characteristics derived from IVUS analysis were 
      compared between those who displayed myocardial bridge versus those who did not 
      harbour the anomaly. RESULTS: One hundred and forty-seven (147) patients 
      underwent IVUS guided PCI. Incidence of MB was 44/147 (29.9%). Mean age of 
      patients who had MB + was higher (62.1 +/- 10.3 vs. 57.8 +/- 11.2 (p = .03). 
      142/147 (96.6%) patients presented with ACS. ST elevation myocardial infarction 
      (STEMI) was the most common presenting diagnosis (110/147 to 74.8%). There were 
      no differences in qualitative plaque characteristics - attenuated plaque, 
      calcification or calcium score between two groups. Plaque burden and length of 
      the lesion in the proximal vessel were not different. Among patients with MB +, 
      atheromatous extension to segments underlying the bridge was seen in 31/44 
      (70.5%) cases. CONCLUSIONS: In a series of patients who presented with advanced 
      clinical atherosclerosis, plaque characteristics were not different in patients 
      who harboured myocardial bridge vs. those who did not have the anomaly. 
      Atheromatous involvement was seen extending into bridged segment contrary to 
      previous reports.
FAU - Narayanan, Sajan
AU  - Narayanan S
AUID- ORCID: 0000-0003-4000-4041
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Joseph, Stigi
AU  - Joseph S
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Varghese, Anwar Chennakkadan
AU  - Varghese AC
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Nair, Rajesh Govindan
AU  - Nair RG
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Mohan, Hareesh
AU  - Mohan H
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Edger, Denim
AU  - Edger D
AD  - Little Flower Hospital & Research Institute, Angamaly, India.
FAU - Sudhakar, Abish
AU  - Sudhakar A
AD  - Amrita Institute of Medical Sciences, Kochi, India.
LA  - eng
PT  - Journal Article
DEP - 20230320
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
SB  - IM
MH  - Humans
MH  - *Coronary Artery Disease/complications
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Ultrasonography, Interventional
MH  - *Plaque, Atherosclerotic/diagnostic imaging/complications
MH  - Coronary Vessels/diagnostic imaging/pathology
MH  - *Acute Coronary Syndrome/diagnostic imaging/epidemiology
MH  - *Atherosclerosis
MH  - Coronary Angiography/adverse effects
OTO - NOTNLM
OT  - Myocardial bridging
OT  - acute coronary syndrome
OT  - atherosclerosis
OT  - intravascular ultrasound
OT  - plaque burden
OT  - remodelling index
EDAT- 2023/03/21 06:00
MHDA- 2023/09/29 06:44
CRDT- 2023/03/20 09:52
PHST- 2023/09/29 06:44 [medline]
PHST- 2023/03/21 06:00 [pubmed]
PHST- 2023/03/20 09:52 [entrez]
AID - 10.1080/00015385.2023.2187117 [doi]
PST - ppublish
SO  - Acta Cardiol. 2023 Oct;78(8):894-900. doi: 10.1080/00015385.2023.2187117. Epub 
      2023 Mar 20.