PMID- 36940919
OWN - NLM
STAT- MEDLINE
DCOM- 20230516
LR  - 20230516
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 167
DP  - 2023 Jun
TI  - Nature-inspired synthesis of antibacterial glucovanillin derivatives.
PG  - 105475
LID - S0367-326X(23)00050-3 [pii]
LID - 10.1016/j.fitote.2023.105475 [doi]
AB  - The ongoing threat of Antimicrobial Resistance (AMR) complicated by the rise of 
      Multidrug-Resistant (MDR) pathogens calls for increased efforts in the search for 
      novel treatment options. While deriving inspiration from antibacterial natural 
      compounds, this study aimed at using synthetic approaches to generate a series of 
      glucovanillin derivatives and explore their antibacterial potentials. Among the 
      synthesized derivatives, optimum antibacterial activities were exhibited by those 
      containing 2,4- and 3,5-dichlorophenylamino group coupled to a glucovanillin 
      moiety (compounds 6h and 8d respectively). In those compounds, the Minimum 
      Inhibitory Concentrations (MIC) of 128-256 mug/mL were observed against reference 
      and MDR strains of Klebsiella pneumoniae, Methicillin-resistant Staphylococcus 
      aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). Moreover, 
      these findings emphasize the claims from previous reports on the essence of 
      smaller molecular size, the presence of protonatable amino groups and halogens in 
      potential antibacterial agents. The observed moderate and broad-spectrum 
      activities of the stated derivatives point to their suitability as potential 
      leads towards further efforts to improve their antibacterial activities.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Masota, Nelson E
AU  - Masota NE
AD  - Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland C7, 
      97074 Wuerzburg, Germany; School of Pharmacy, Muhimbili University of Health and 
      Allied Sciences, P.O. Box 65013, Upanga West, Dar es Salaam, Tanzania.
FAU - Ohlsen, Knut
AU  - Ohlsen K
AD  - Institute for Molecular Infection Biology, University of Wuerzburg, 
      Josef-Schneider-Strasse 2, 97080 Wuerzburg, Germany.
FAU - Meinel, Lorenz
AU  - Meinel L
AD  - Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland C7, 
      97074 Wuerzburg, Germany.
FAU - Holzgrabe, Ulrike
AU  - Holzgrabe U
AD  - Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland C7, 
      97074 Wuerzburg, Germany. Electronic address: Ulrike.holzgrabe@uni-wuerzburg.de.
LA  - eng
PT  - Journal Article
DEP - 20230320
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - H81U1KBS6E (glucovanillin)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Benzaldehydes)
SB  - IM
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Molecular Structure
MH  - Anti-Bacterial Agents/pharmacology
MH  - Benzaldehydes
MH  - Microbial Sensitivity Tests
OTO - NOTNLM
OT  - Antibacterial
OT  - Enterobacteriaceae
OT  - MDR
OT  - MRSA
OT  - VRE
COIS- Declaration of Competing Interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Nelson Masota reports financial support was provided by German 
      Academic Exchange Service.
EDAT- 2023/03/21 06:00
MHDA- 2023/05/16 06:42
CRDT- 2023/03/20 20:25
PHST- 2022/12/23 00:00 [received]
PHST- 2023/03/16 00:00 [revised]
PHST- 2023/03/16 00:00 [accepted]
PHST- 2023/05/16 06:42 [medline]
PHST- 2023/03/21 06:00 [pubmed]
PHST- 2023/03/20 20:25 [entrez]
AID - S0367-326X(23)00050-3 [pii]
AID - 10.1016/j.fitote.2023.105475 [doi]
PST - ppublish
SO  - Fitoterapia. 2023 Jun;167:105475. doi: 10.1016/j.fitote.2023.105475. Epub 2023 
      Mar 20.