PMID- 36941321
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230417
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Mar 20
TI  - Application of a linear interpolation algorithm in radiation therapy dosimetry 
      for 3D dose point acquisition.
PG  - 4539
LID - 10.1038/s41598-023-31562-3 [doi]
LID - 4539
AB  - Air-vented ion chambers are generally used in radiation therapy dosimetry to 
      determine the absorbed radiation dose with superior precision. However, in ion 
      chamber detector arrays, the number of array elements and their spacing do not 
      provide sufficient spatial sampling, which can be overcome by interpolating 
      measured data. Herein, we investigated the potential principle of the linear 
      interpolation algorithm in volumetric dose reconstruction based on computed 
      tomography images in the volumetric modulated arc therapy (VMAT) technique and 
      evaluated how the ion chamber spacing and anatomical mass density affect the 
      accuracy of interpolating new data points. Plane measurement doses on 83 VMAT 
      treatment plans at different anatomical sites were acquired using Octavius 729, 
      Octavius1500, and MatriXX ion chamber detector arrays, followed by the linear 
      interpolation to reconstruct volumetric doses. Dosimetric differences in planning 
      target volumes (PTVs) and organs at risk (OARs) between treatment planning system 
      and reconstruction were evaluated by dose volume histogram metrics. The average 
      percentage dose deviations in the mean dose (D(mean)) of PTVs reconstructed by 
      729 and 1500 arrays ranged from 4.7 to 7.3% and from 1.5 to 2.3%, while the 
      maximum dose (D(max)) counterparts ranged from 2.3 to 5.5% and from 1.6 to 7.6%, 
      respectively. The average percentage dose/volume deviations of mixed PTVs and 
      OARs in the abdomen/gastric and pelvic sites were 7.6%, 3.5%, and 7.2%, while 
      mediastinum and lung plans showed slightly larger values of 8.7%, 5.1%, and 8.9% 
      for 729, 1500, and MatriXX detector arrays, respectively. Our findings indicated 
      that the smaller the spacing between neighbouring detectors and the more ion 
      chambers present, the smaller the error in interpolating new data points. 
      Anatomical regions with small local mass density inhomogeneity were associated 
      with superior dose reconstruction. Given a large mass density difference in the 
      various human anatomical structures and the characteristics of the linear 
      interpolation algorithm, we suggest that an alternative data interpolation method 
      should be used in radiotherapy dosimetry.
CI  - (c) 2023. The Author(s).
FAU - Guo, Yixiao
AU  - Guo Y
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China.
FAU - Li, Bo
AU  - Li B
AD  - Department of Bone and Soft-Tissue Carcinoma, Gansu Provincial Hospital, Lanzhou, 
      730000, People's Republic of China.
FAU - Li, Yazhou
AU  - Li Y
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China.
FAU - Du, Wen
AU  - Du W
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China.
FAU - Feng, Weigui
AU  - Feng W
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China.
FAU - Feng, Shifang
AU  - Feng S
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China.
FAU - Miao, Guoying
AU  - Miao G
AD  - Department of Radiation Oncology, Gansu Provincial Hospital, Lanzhou, 730000, 
      People's Republic of China. 106808941@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230320
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiometry/methods
MH  - Algorithms
MH  - *Radiotherapy, Intensity-Modulated/methods
PMC - PMC10027884
COIS- The authors declare no competing interests.
EDAT- 2023/03/22 06:00
MHDA- 2023/03/23 06:00
PMCR- 2023/03/20
CRDT- 2023/03/21 00:18
PHST- 2022/12/28 00:00 [received]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/03/21 00:18 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/23 06:00 [medline]
PHST- 2023/03/20 00:00 [pmc-release]
AID - 10.1038/s41598-023-31562-3 [pii]
AID - 31562 [pii]
AID - 10.1038/s41598-023-31562-3 [doi]
PST - epublish
SO  - Sci Rep. 2023 Mar 20;13(1):4539. doi: 10.1038/s41598-023-31562-3.