PMID- 36941487
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230322
IS  - 1432-072X (Electronic)
IS  - 0302-8933 (Linking)
VI  - 205
IP  - 4
DP  - 2023 Mar 20
TI  - In silico evolutionary and structural analysis of cAMP response proteins (CARPs) 
      from Leishmania major.
PG  - 125
LID - 10.1007/s00203-023-03463-6 [doi]
AB  - With unidentified chemical triggers and novel-effectors, cAMP signaling is 
      broadly noncanonical in kinetoplastida parasites. Though novel protein kinase A 
      regulatory subunits (PKAR) have been identified earlier, cAMP Response Proteins 
      (CARPs) have been identified as a unique and definite cAMP effector of 
      trypanosomatids. CARP1-CARP4 emerged as critical regulatory components of cAMP 
      signaling pathway in Trypanosoma with evidences that CARP3 can directly interact 
      with a flagellar adenylate cyclase (AC). CARP-mediated regulations, identified so 
      far, reflects the mechanistic diversity of cAMP signaling. Albeit the function of 
      the orthologous is not yet delineated, in kinetoplastids like Leishmania, 
      presence of CARP1, 2 and 4 orthologues suggests existence of conserved effector 
      mechanisms. Targeting CARP orthologues in Leishmania, a comprehensive 
      evolutionary analysis of CARPs have been aimed in this study which revealed 
      phylogenetic relationship, codon adaptation and structural heterogeneity among 
      the orthologues, warranting functional analysis in future to explore their 
      involvement in infectivity.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Bhakta, Swarnav
AU  - Bhakta S
AD  - Department of Biotechnology, Adamas University, Barasat-Barrackpore Rd., Kolkata, 
      700126, India.
FAU - Bhattacharya, Arijit
AU  - Bhattacharya A
AD  - Department of Microbiology, Adamas University, Barasat-Barrackpore Rd., Kolkata, 
      700126, India. arijit.bhattacharya@adamasuniversity.ac.in.
LA  - eng
GR  - AU/REG/2019-20/12/008/Adamas University/
GR  - SRG/2020/000702/Science and Engineering Research Board/
PT  - Journal Article
DEP - 20230320
PL  - Germany
TA  - Arch Microbiol
JT  - Archives of microbiology
JID - 0410427
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - *Leishmania major/genetics/metabolism
MH  - Cyclic AMP/metabolism
MH  - Phylogeny
MH  - Signal Transduction/physiology
MH  - *Carps
OTO - NOTNLM
OT  - Adenylate cyclase
OT  - Cyclic AMP response proteins
OT  - Horizontal gene transfer
OT  - Phylogeny
EDAT- 2023/03/22 06:00
MHDA- 2023/03/23 06:00
CRDT- 2023/03/21 00:27
PHST- 2023/01/04 00:00 [received]
PHST- 2023/03/02 00:00 [accepted]
PHST- 2023/03/01 00:00 [revised]
PHST- 2023/03/21 00:27 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/23 06:00 [medline]
AID - 10.1007/s00203-023-03463-6 [pii]
AID - 10.1007/s00203-023-03463-6 [doi]
PST - epublish
SO  - Arch Microbiol. 2023 Mar 20;205(4):125. doi: 10.1007/s00203-023-03463-6.