PMID- 36941633
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230323
IS  - 2045-3701 (Print)
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Mar 20
TI  - The versatile roles of testrapanins in cancer from intracellular signaling to 
      cell-cell communication: cell membrane proteins without ligands.
PG  - 59
LID - 10.1186/s13578-023-00995-8 [doi]
LID - 59
AB  - The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 
      members in mammals. They are variably expressed on the cell surface, various 
      intracellular organelles and vesicles in nearly all cell types. Different from 
      the majority of cell membrane proteins, TSPANs do not have natural ligands. 
      TSPANs typically organize laterally with other membrane proteins to form 
      tetraspanin-enriched microdomains (TEMs) to influence cell adhesion, migration, 
      invasion, survival and induce downstream signaling. Emerging evidence shows that 
      TSPANs can regulate not only cancer cell growth, metastasis, stemness, drug 
      resistance, but also biogenesis of extracellular vesicles (exosomes and 
      migrasomes), and immunomicroenvironment. This review summarizes recent studies 
      that have shown the versatile function of TSPANs in cancer development and 
      progression, or the molecular mechanism of TSPANs. These findings support the 
      potential of TSPANs as novel therapeutic targets against cancer.
CI  - (c) 2023. The Author(s).
FAU - Zhou, Zhihang
AU  - Zhou Z
AUID- ORCID: 0000-0003-1356-9872
AD  - Department of Gastroenterology, The Second Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China. zhouzhihang@cqmu.edu.cn.
AD  - Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City 
      University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, SAR, People's 
      Republic of China. zhouzhihang@cqmu.edu.cn.
FAU - Yang, Zihan
AU  - Yang Z
AD  - Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City 
      University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, SAR, People's 
      Republic of China.
AD  - Department of Precision Diagnostic and Therapeutic Technology, City University of 
      Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
FAU - Zhou, Li
AU  - Zhou L
AD  - Department of Gastroenterology, The Second Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
AD  - Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City 
      University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, SAR, People's 
      Republic of China.
FAU - Yang, Mengsu
AU  - Yang M
AD  - Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City 
      University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, SAR, People's 
      Republic of China.
AD  - Department of Precision Diagnostic and Therapeutic Technology, City University of 
      Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
FAU - He, Song
AU  - He S
AD  - Department of Gastroenterology, The Second Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China. hedoctor65@cqmu.edu.cn.
LA  - eng
GR  - 81972285/National Natural Science Fund/
GR  - CSTB2022NSCQ-MSX1038/the Natural Science Foundation of Chongqing/
GR  - CSTB2022NSCQ-MSX0775/the Natural Science Foundation of Chongqing/
GR  - 13-004-009/Senior Medical Talents Program of Chongqing for Young and Middle-aged 
      and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing 
      Medical University/
GR  - 13-002-011/Senior Medical Talents Program of Chongqing for Young and Middle-aged 
      and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing 
      Medical University/
GR  - HZQB-KCZYZ-2021017/Hetao Shenzhen-Hong Kong Science and Technology Innovation 
      Cooperation Zone Shenzhen Park Project/
PT  - Journal Article
PT  - Review
DEP - 20230320
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC10025802
OTO - NOTNLM
OT  - Cancer
OT  - Extracellular vesicles
OT  - Immunonology
OT  - Metastasis
OT  - Tetraspanin
COIS- The authors declare that they have no affiliations with or involvement in any 
      organization or entity with any financial interest in the subject matter or 
      materials discussed in this manuscript.
EDAT- 2023/03/22 06:00
MHDA- 2023/03/22 06:01
PMCR- 2023/03/20
CRDT- 2023/03/21 00:38
PHST- 2023/01/06 00:00 [received]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/03/21 00:38 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/22 06:01 [medline]
PHST- 2023/03/20 00:00 [pmc-release]
AID - 10.1186/s13578-023-00995-8 [pii]
AID - 995 [pii]
AID - 10.1186/s13578-023-00995-8 [doi]
PST - epublish
SO  - Cell Biosci. 2023 Mar 20;13(1):59. doi: 10.1186/s13578-023-00995-8.