PMID- 36941887
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230322
IS  - 2399-5300 (Electronic)
IS  - 2399-5300 (Linking)
VI  - 7
IP  - 2
DP  - 2023
TI  - Assessing Healthy Aging Score and Its Association With All-Cause Mortality: 
      Findings From the China Health and Retirement Longitudinal Study.
PG  - igad006
LID - 10.1093/geroni/igad006 [doi]
LID - igad006
AB  - BACKGROUND AND OBJECTIVES: To construct a comprehensive healthy aging score (HAS) 
      and explore its association with all-cause mortality and its potential 
      interactions with other demographics on mortality. RESEARCH DESIGN AND METHODS: 
      This study included 5,409 participants aged >/=60 years from the China Health and 
      Retirement Longitudinal Study. An HAS was constructed based on three dimensions 
      of healthy aging including intrinsic capacity (IC), environmental support (ES), 
      and chronic disease (CD), which were assessed at baseline, and categorized by 
      tertiles (poor, moderate, and high). Participants were followed up biennially for 
      all-cause mortality through the death registration or family interview from 2011 
      to 2018. Data were analyzed using Cox regression, Laplace regression, and 
      receiver-operating characteristic analysis. RESULTS: During 7 years of follow-up, 
      877 (16.21%) participants died. An HAS was constructed based on the cognition, 
      mobility, and instrumental activity of daily living in the IC dimension; housing 
      in the ES dimension; and hypertension, diabetes, chronic lung disease, stroke, 
      and cancer in the CD dimension, which was associated with death. HAS seems a good 
      predictor of all-cause mortality, with an area under the curve of 0.749. The 
      hazard ratios and 95% confidence intervals for all-cause mortality related to 
      moderate and poor HAS (vs high HAS) were 1.26 (1.01-1.56) and 2.38 (1.94-2.91), 
      respectively. The median survival time was 2.46 years shorter in participants 
      with poor HAS than those with high HAS. There were significant additive 
      interactions of HAS with age, sex, and marital status on death. DISCUSSION AND 
      IMPLICATIONS: Poor HAS may increase mortality and shorten survival, especially 
      among older, male, and single adults.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of The 
      Gerontological Society of America.
FAU - Zeng, Zihang
AU  - Zeng Z
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Li, Xuerui
AU  - Li X
AD  - Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 
      Geriatrics Institute, Tianjin, China.
FAU - Yang, Wenzhe
AU  - Yang W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Wang, Jiao
AU  - Wang J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Zhu, Yun
AU  - Zhu Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Qi, Xiuying
AU  - Qi X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Xu, Weili
AU  - Xu W
AUID- ORCID: 0000-0001-6140-2968
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Aging Research Center, Department of Neurobiology, Care Sciences and Society, 
      Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20230130
PL  - England
TA  - Innov Aging
JT  - Innovation in aging
JID - 101703706
PMC - PMC10024481
OTO - NOTNLM
OT  - Chronic diseases
OT  - Cohort study
OT  - Environmental support
OT  - Healthy aging
OT  - Intrinsic capacity
COIS- The authors declared no conflict of interest.
EDAT- 2023/03/22 06:00
MHDA- 2023/03/22 06:01
PMCR- 2023/01/30
CRDT- 2023/03/21 02:05
PHST- 2022/07/11 00:00 [received]
PHST- 2023/03/21 02:05 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/22 06:01 [medline]
PHST- 2023/01/30 00:00 [pmc-release]
AID - igad006 [pii]
AID - 10.1093/geroni/igad006 [doi]
PST - epublish
SO  - Innov Aging. 2023 Jan 30;7(2):igad006. doi: 10.1093/geroni/igad006. eCollection 
      2023.