PMID- 36942072
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230322
IS  - 1726-6890 (Electronic)
IS  - 1735-0328 (Print)
IS  - 1726-6882 (Linking)
VI  - 21
IP  - 1
DP  - 2022 Dec
TI  - Phytochemical Analysis and Biological Activity of Salvia compressa Vent.
PG  - e127031
LID - 10.5812/ijpr-127031 [doi]
LID - e127031
AB  - BACKGROUND: Salvia extracts have various biological activities and are rich 
      sources of bioactive metabolites. OBJECTIVES: We identified five phytochemicals 
      from S. compressa extract and assessed its biological properties. METHODS: The 
      plant's shoots were extracted using dichloromethane, and the constituents were 
      isolated using column chromatography. High-resolution NMR spectroscopy 
      characterized the chemical structures of the compounds (1 - 5). The cytotoxic 
      effect of the extract was examined against MCF-7 cells by MTT reduction assay, 
      while cisplatin was tested as a reference cytotoxic compound. The antibacterial 
      activity was assessed using nutrient broth micro-dilution (NBMD), and 
      chloramphenicol was used as the positive control. RESULTS: Citrostadienol (1), 
      beta-sitosterol (2), two glyceride esters of linolenic, linoleic, and palmitic acids 
      (3, 4), and geraniol (5) were isolated from S. compressa for the first time. The 
      extract showed activity against MCF-7 breast cancer cells and reduced cell 
      viability to 68.2 +/- 13.1% compared to the control drug at the concentration of 50 
      microg/mL, while it was not active against seven test bacteria. CONCLUSIONS: The 
      anti-complementary activity of the isolated steroids suggests S. compressa for 
      future anti-inflammatory research.
CI  - Copyright (c) 2022, Author(s).
FAU - Noorbakhsh, Firoozeh
AU  - Noorbakhsh F
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Zare, Somayeh
AU  - Zare S
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Firuzi, Omidreza
AU  - Firuzi O
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Sakhteman, Amirhossein
AU  - Sakhteman A
AD  - Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Chandran, Jima N
AU  - Chandran JN
AD  - Research Group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, 
      Germany.
FAU - Schneider, Bernd
AU  - Schneider B
AUID- ORCID: 0000-0003-4788-1565
AD  - Research Group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, 
      Germany.
FAU - Jassbi, Amir Reza
AU  - Jassbi AR
AUID- ORCID: 0000-0003-3918-361X
AD  - Medicinal and Natural Products Chemistry Research Center, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220909
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC10024313
OTO - NOTNLM
OT  - Cytotoxic Activity
OT  - Geraniol
OT  - Salvia compressa Vent
OT  - Steroids
COIS- Conflict of Interests: ARJ is reviewer of IJPR. The paper was supported by a 
      NIMAD Grant. There is no support from any company in which the authors have stock 
      shares. No patents and no consultant fees are earned regarding this manuscript. 
      Omidreza Firuzi is not an editorial member of IJPR but may be a reviewer of some 
      papers in IJPR.
EDAT- 2023/03/22 06:00
MHDA- 2023/03/22 06:01
PMCR- 2022/09/09
CRDT- 2023/03/21 02:13
PHST- 2022/04/25 00:00 [received]
PHST- 2022/08/01 00:00 [revised]
PHST- 2022/08/11 00:00 [accepted]
PHST- 2023/03/21 02:13 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/22 06:01 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - 10.5812/ijpr-127031 [doi]
PST - epublish
SO  - Iran J Pharm Res. 2022 Sep 9;21(1):e127031. doi: 10.5812/ijpr-127031. eCollection 
      2022 Dec.