PMID- 36942188
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230322
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Feb
TI  - Feasibility and Acceptability of Online Recruitment and an Online Brief 
      Mindfulness Intervention Among Patients With Sickle Cell Disease.
PG  - e35073
LID - 10.7759/cureus.35073 [doi]
LID - e35073
AB  - Background Pain among young adult patients with sickle cell disease (PWSCD) is a 
      highly significant public health problem associated with reduced quality of life. 
      Due to issues uniquely affecting PWSCD, including distrust of research, 
      challenging life situations, debilitating pain, stigma, and logistical challenges 
      (e.g., child or elder care and transportation), SCD researchers often find it 
      challenging to meet sample size and enrollment targets. To our knowledge, all 
      known SCD studies have solely recruited participants in person (e.g., clinics and 
      local organizations) and utilized lengthy interventions with suboptimal 
      recruitment and retention results. Newer recruitment methods, such as online 
      recruitment, need to be explored for research among PWSCD. In this pilot project, 
      we sought to address these challenges by investigating: 1) a novel method of 
      using online outreach to recruit/enroll young PWSCD and 2) a novel, brief online 
      mindfulness intervention adapted from Mindfulness-Oriented Recovery Enhancement 
      (MORE): Mini-MORE designed to treat pain among PWSCD.  Methods Participants (N = 
      32) were recruited online (e.g., paid advertisements on Facebook and NextDoor; 
      free advertisements on Facebook groups and Reddit) and screened by phone from 
      October 25 to November 8, 2022. Participants watched an online Mini-MORE video. 
      Immediately before and after watching the video, participants rated their pain 
      intensity and unpleasantness on an 11-point numeric rating scale (NRS). 
      Afterward, participants were emailed an individualized link to additional audio 
      recordings for ongoing practice. Immediately before and after accessing the 
      additional recordings, participants rated their pain intensity, anxiety, and 
      depression on an 11-point NRS. T-tests were used to examine the impact of Mini 
      MORE on outcomes at two-time points. Results A total of 84 participants completed 
      the self-screening. The majority of self-screeners resulted from free posts in 
      Facebook groups (77%), Reddit (1%), and Craigslist (6%). Thirty-two (32) eligible 
      participants agreed to join a Zoom meeting to watch the video. The entire 
      Mini-MORE video was viewed by 31 of 32 participants (97%). Pain intensity 
      decreased by 1.7 points (p<0.001, Cohen's d=2.19), and pain unpleasantness 
      decreased by 2.1 points (p<0.001, Cohen's d=2.20). Listening to the supplemental 
      recordings was associated with significant, immediate decreases in pain intensity 
      by 1.3 points (p=0.015, Cohen's d=2.05), anxiety by 1.8 points (p=0.022, 
      Cohen's d=3.10), and depression by 1.74 points (p=0.019, Cohen's d=2.94). 
      Conclusions Results suggest that online methods are feasible in recruiting and 
      enrolling young PWSCD, and the online Mini-MORE intervention is acceptable among 
      PWSCD. Future research is needed to assess whether Mini-MORE is associated with 
      decreased pain symptomology in young PWSCD.
CI  - Copyright (c) 2023, Ugarte et al.
FAU - Ugarte, Dominic Arjuna B
AU  - Ugarte DAB
AD  - Emergency Medicine, University of California Irvine, Orange County, USA.
FAU - Hanley, Adam
AU  - Hanley A
AD  - Psychology, College of Social Work, The University of Utah, Salt Lake City, USA.
FAU - Dusek, Jeffery A
AU  - Dusek JA
AD  - Integrative/Complementary Medicine, Connor Whole Health, University Hospitals 
      Cleveland Medical Center, Cleveland, USA.
FAU - Martin, Sarah
AU  - Martin S
AD  - Anesthesiology, University of California Irvine, Orange County, USA.
FAU - Cumberland, William
AU  - Cumberland W
AD  - Biostatistics, University of California, Los Angeles, Los Angeles, USA.
FAU - Young, Sean
AU  - Young S
AD  - Emergency Medicine, University of California Irvine, Orange County, USA.
LA  - eng
PT  - Journal Article
DEP - 20230216
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10024608
OTO - NOTNLM
OT  - mindfulness meditation
OT  - mindfulness-based therapy
OT  - pain rating
OT  - sickle cell crisis
OT  - sickle cell disease (scd)
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/22 06:00
MHDA- 2023/03/22 06:01
PMCR- 2023/02/16
CRDT- 2023/03/21 02:16
PHST- 2023/02/16 00:00 [accepted]
PHST- 2023/03/21 02:16 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/22 06:01 [medline]
PHST- 2023/02/16 00:00 [pmc-release]
AID - 10.7759/cureus.35073 [doi]
PST - epublish
SO  - Cureus. 2023 Feb 16;15(2):e35073. doi: 10.7759/cureus.35073. eCollection 2023 
      Feb.