PMID- 36942204
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230322
IS  - 1013-9052 (Print)
IS  - 1658-3558 (Electronic)
IS  - 1013-9052 (Linking)
VI  - 35
IP  - 2
DP  - 2023 Feb
TI  - Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus 
      norvegicus accelerates and enhances osteogenesis activity and implant 
      osseointegration.
PG  - 147-153
LID - 10.1016/j.sdentj.2023.01.003 [doi]
AB  - Peri-implantitis additional treatment generally aims to repair damaged tissue 
      through a regenerative approach. Human umbilical cord mesenchymal stem cells 
      (hUCMSCs) produce a high osteogenic effect and are capable of modulating the 
      immune system by suppressing inflammatory response, modulating bone resorption, 
      and inducing endogenous osteogenesis. AIM: This study was intended to discover 
      the effect of hUCMSCs on an implant osseointegration process in peri-implantitis 
      rat subjects as assessed by several markers including interleukin-10 (IL-10), 
      transforming growth factor-beta (TGF-beta), receptor activator of nuclear factor kappa- 
      beta ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and 
      osteoprotegerin (OPG). MATERIAL AND METHODS: The research design implemented 
      during this study represented a true experimental design incorporating the use of 
      Rattus norvegicus (Wistar strain) as subjects. RESULTS: Data analysed by means of 
      a Brown Forsythe test indicated differences between the increase in BMP-2 
      expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL 
      expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). 
      CONCLUSION: According to the findings of this research, hUCMSCs induction is 
      successful in accelerating and enhancing osteogenic activity and implant 
      osseointegration in peri-implantitis rat subjects.
CI  - (c) 2023 The Authors.
FAU - Hendrijantini, Nike
AU  - Hendrijantini N
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Kuntjoro, Mefina
AU  - Kuntjoro M
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Agustono, Bambang
AU  - Agustono B
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Maya Sitalaksmi, Ratri
AU  - Maya Sitalaksmi R
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Dimas Aditya Ari, Muhammad
AU  - Dimas Aditya Ari M
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Theodora, Marcella
AU  - Theodora M
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Effendi, Rudy
AU  - Effendi R
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Setiawan Djuarsa, Ivan
AU  - Setiawan Djuarsa I
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Widjaja, Jennifer
AU  - Widjaja J
AD  - Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Sosiawan, Agung
AU  - Sosiawan A
AD  - Department of Dental Public Health, Faculty of Dental Medicine, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Hong, Guang
AU  - Hong G
AD  - Division for Globalization Initiative, Graduate School of Dentistry, Tohoku 
      University, Sendai, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - Saudi Arabia
TA  - Saudi Dent J
JT  - The Saudi dental journal
JID - 9313603
PMC - PMC10024080
OTO - NOTNLM
OT  - Human umbilical cord mesenchymal stem cells
OT  - Implant
OT  - Medicine
OT  - Osseointegration
OT  - Peri-implantitis
EDAT- 2023/03/22 06:00
MHDA- 2023/03/22 06:01
PMCR- 2023/01/05
CRDT- 2023/03/21 02:16
PHST- 2022/08/25 00:00 [received]
PHST- 2022/12/27 00:00 [revised]
PHST- 2023/01/02 00:00 [accepted]
PHST- 2023/03/21 02:16 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/22 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - S1013-9052(23)00003-2 [pii]
AID - 10.1016/j.sdentj.2023.01.003 [doi]
PST - ppublish
SO  - Saudi Dent J. 2023 Feb;35(2):147-153. doi: 10.1016/j.sdentj.2023.01.003. Epub 
      2023 Jan 5.