PMID- 36944353
OWN - NLM
STAT- MEDLINE
DCOM- 20230727
LR  - 20230727
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 44
IP  - 9
DP  - 2023 Jul
TI  - Resistance Training Improves Hypertrophic and Mitochondrial Adaptation in 
      Skeletal Muscle.
PG  - 625-633
LID - 10.1055/a-2059-9175 [doi]
AB  - Resistance training is employed for pursuing muscle strength characterized by 
      activation of mammalian target of rapamycin (mTOR)-mediated hypertrophic 
      signaling for protein production. Endurance training elevates peroxisome 
      proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) signaling of 
      mitochondrial adaptations for oxidative phosphorylation. Now, emerging evidence 
      suggests that, like endurance training, resistance training also elicits profound 
      effects on mitochondrial adaptations in skeletal muscle, which means that 
      resistance training yields both strength and endurance phenotypes in myofibers, 
      which has treatment value for the muscle loss and poor aerobic capacity in 
      humans. Our review outlines a brief overview of muscle hypertrophic signals with 
      resistance training, and focuses on the effects of resistance training on 
      mitochondrial biogenesis and respiration in skeletal muscle. This study provides 
      novel insights into the therapeutic strategy of resistance training for the 
      metabolically dysfunctional individuals with declined mitochondrial function.
CI  - Thieme. All rights reserved.
FAU - Zhao, Yong-Cai
AU  - Zhao YC
AD  - Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, College of 
      Exercise and Health, Tianjin University of Sport, Tianjin, China.
FAU - Wu, Yan-Yan
AU  - Wu YY
AD  - Department of Physical Education, Tianjin University of Science and Technology, 
      Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230321
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Transcription Factors)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
SB  - IM
MH  - Humans
MH  - *Transcription Factors/genetics
MH  - *Resistance Training
MH  - Mitochondria/metabolism
MH  - Signal Transduction/physiology
MH  - Muscle, Skeletal/physiology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
COIS- The authors declared there was no conflict of interest.
EDAT- 2023/03/22 06:00
MHDA- 2023/07/27 06:43
CRDT- 2023/03/21 19:52
PHST- 2023/07/27 06:43 [medline]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/21 19:52 [entrez]
AID - 10.1055/a-2059-9175 [doi]
PST - ppublish
SO  - Int J Sports Med. 2023 Jul;44(9):625-633. doi: 10.1055/a-2059-9175. Epub 2023 Mar 
      21.