PMID- 36944362
OWN - NLM
STAT- MEDLINE
DCOM- 20231117
LR  - 20231117
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 130
IP  - 10
DP  - 2023 Nov 28
TI  - FTO: a critical role in obesity and obesity-related diseases.
PG  - 1657-1664
LID - 10.1017/S0007114523000764 [doi]
AB  - In recent years, obesity is a growing pandemic in the world and has likely 
      contributed to increasing the incidence of obesity-related diseases. Fat mass and 
      obesity-associated gene (FTO) is the first gene discovered which has a close 
      connection with fat. Recent studies suggested that FTO gene has played an 
      important role in the molecular mechanisms of many diseases. Obesity is 
      considered to be a hereditary disease and can evoke many kinds of diseases, 
      including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), 
      cancer, etc., whose exact possible molecular mechanisms responsible for the 
      effect of FTO on obesity and obesity-related diseases remain largely unknown. In 
      this review, we comprehensively discuss the correlation between FTO gene and 
      obesity, cancer, PCOS, T2DM, as well as the molecular mechanism involved in these 
      diseases.
FAU - Yin, Dan
AU  - Yin D
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Li, Yiyang
AU  - Li Y
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Liao, Xingyue
AU  - Liao X
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Tian, Dewei
AU  - Tian D
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Xu, Yunsi
AU  - Xu Y
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Zhou, Cuilan
AU  - Zhou C
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Li, Suyun
AU  - Li S
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Obstetrics and Gynecology, the Second Affiliated Hospital, 
      University of South China, 30# Jiefang Road, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Nie, Yulin
AU  - Nie Y
AD  - Department of Obstetrics and Gynecology, the Second Affiliated Hospital, 
      University of South China, 30# Jiefang Road, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Liao, Hongqing
AU  - Liao H
AD  - Department of Obstetrics and Gynecology, the Second Affiliated Hospital, 
      University of South China, 30# Jiefang Road, Hengyang, Hunan421001, People's 
      Republic of China.
FAU - Peng, Cuiying
AU  - Peng C
AUID- ORCID: 0000-0002-8689-1873
AD  - Department of Cell Biology and Genetics, Institute of Cytology and Genetics, 
      School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of 
      Ecological Environment and Critical Human Diseases Prevention of Hunan Province 
      Department of Education, Key Laboratory of Hengyang City on Biological Toxicology 
      and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and 
      Health Hazards, University of South China, Hengyang, Hunan421001, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230322
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
RN  - 0 (Proteins)
SB  - IM
MH  - Female
MH  - Humans
MH  - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genotype
MH  - *Obesity/genetics
MH  - *Polycystic Ovary Syndrome/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Proteins
OTO - NOTNLM
OT  - Cancer
OT  - FTO
OT  - Obesity
OT  - PCOS
OT  - SNP
OT  - Type 2 diabetes mellitus
EDAT- 2023/03/22 06:00
MHDA- 2023/10/23 00:42
CRDT- 2023/03/21 20:02
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/21 20:02 [entrez]
AID - S0007114523000764 [pii]
AID - 10.1017/S0007114523000764 [doi]
PST - ppublish
SO  - Br J Nutr. 2023 Nov 28;130(10):1657-1664. doi: 10.1017/S0007114523000764. Epub 
      2023 Mar 22.