PMID- 36944369
OWN - NLM
STAT- MEDLINE
DCOM- 20230323
LR  - 20240210
IS  - 1464-5157 (Electronic)
IS  - 0265-6736 (Linking)
VI  - 40
IP  - 1
DP  - 2023
TI  - Device safety assessment of bronchoscopic microwave ablation of normal swine 
      peripheral lung using robotic-assisted bronchoscopy.
PG  - 2187743
LID - 10.1080/02656736.2023.2187743 [doi]
AB  - INTRODUCTION: The aim of this study was to assess the safety of bronchoscopic 
      microwave ablation (MWA) of peripheral lung parenchyma using the NEUWAVE FLEX 
      Microwave Ablation System, and robotic-assisted bronchoscopy (RAB) using the 
      MONARCH Platform in a swine model. METHODS: Computed tomography (CT)-guided RAB 
      MWA was performed in the peripheral lung parenchyma of 17 Yorkshire swine 
      (40-50 kg) and procedural adverse events (AEs) documented. The acute group (day 
      0, n = 5) received 4 MWAs at 100 W for 1, 3, 5, and 10 min in 4 different lung 
      lobes. Subacute and chronic groups (days 3 and 30, n = 6 each) received one MWA 
      (100 W, 10 min) per animal. RESULTS: The study was completed without major 
      procedural complications. No postprocedural AEs including death, pneumothorax, 
      bronchopleural fistula, hemothorax, or pleural effusions were observed. No gross 
      or histological findings suggestive of thromboembolism were found in any organ. 
      One 3-Day and one 30-Day swine exhibited coughing that required no medication 
      (minor AEs), and one 30-Day animal required antibiotic medication (major AE) for 
      a suspected lower respiratory tract infection that subsided after two weeks. 
      CT-based volumetric estimates of ablation zones in the acute group increased in 
      an ablation time-dependent (1-10 min) manner, whereas macroscopy-based estimates 
      showed an increasing trend in ablation zone size. CONCLUSION: The NEUWAVE FLEX 
      and MONARCH devices were safely used to perform single or multiple RAB MWAs. The 
      preclinical procedural safety profile of RAB MWA supports clinical research of 
      both devices to investigate efficacy in select patients with oligometastatic 
      disease or primary NSCLC.
FAU - De Leon, Hector
AU  - De Leon H
AUID- ORCID: 0000-0001-7627-5578
AD  - Ethicon, Inc, Raritan, NJ, USA.
FAU - Royalty, Kevin
AU  - Royalty K
AD  - NeuWave Medical Inc, Madison, WI, USA.
FAU - Mingione, Louie
AU  - Mingione L
AD  - NeuWave Medical Inc, Madison, WI, USA.
FAU - Jaekel, David
AU  - Jaekel D
AD  - Ethicon, Inc, Redwood City, CA, USA.
FAU - Periyasamy, Sarvesh
AU  - Periyasamy S
AD  - School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
FAU - Wilson, David
AU  - Wilson D
AD  - Schneck Pulmonology, Schneck Medical Center, Seymour, IN, USA.
FAU - Laeseke, Paul
AU  - Laeseke P
AD  - School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
FAU - Stoffregen, William C
AU  - Stoffregen WC
AD  - Northstar Preclinical and Pathology Services, LLC, Lake Elmo, MN, USA.
FAU - Muench, Tim
AU  - Muench T
AD  - Ethicon, Inc, Raritan, NJ, USA.
FAU - Matonick, John P
AU  - Matonick JP
AD  - Ethicon, Inc, Raritan, NJ, USA.
FAU - Kaluza, Grzegorz L
AU  - Kaluza GL
AD  - CRF Skirball Center for Innovation, Orangeburg, NY, USA.
FAU - Cipolla, Gustavo
AU  - Cipolla G
AD  - Ethicon, Inc, Raritan, NJ, USA.
LA  - eng
GR  - F30 CA250408/CA/NCI NIH HHS/United States
GR  - T32 GM140935/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Hyperthermia
JT  - International journal of hyperthermia : the official journal of European Society 
      for Hyperthermic Oncology, North American Hyperthermia Group
JID - 8508395
SB  - IM
MH  - Animals
MH  - Swine
MH  - *Robotic Surgical Procedures/adverse effects
MH  - Bronchoscopy
MH  - Microwaves/therapeutic use
MH  - Equipment Safety
MH  - Lung/diagnostic imaging/surgery/pathology
MH  - *Lung Neoplasms/surgery
MH  - *Catheter Ablation/methods
OTO - NOTNLM
OT  - Microwave ablation
OT  - animal model
OT  - bronchoscopic microwave ablation
OT  - computed tomography
OT  - lung cancer
OT  - robotic bronchoscopy
OT  - thermal ablation
EDAT- 2023/03/22 06:00
MHDA- 2023/03/24 06:00
CRDT- 2023/03/21 20:02
PHST- 2023/03/21 20:02 [entrez]
PHST- 2023/03/22 06:00 [pubmed]
PHST- 2023/03/24 06:00 [medline]
AID - 10.1080/02656736.2023.2187743 [doi]
PST - ppublish
SO  - Int J Hyperthermia. 2023;40(1):2187743. doi: 10.1080/02656736.2023.2187743.