PMID- 36945681
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230323
IS  - 1178-6973 (Print)
IS  - 1178-6973 (Electronic)
IS  - 1178-6973 (Linking)
VI  - 16
DP  - 2023
TI  - Molecular Epidemiology of Community-Acquired Methicillin-Resistant Staphylococcus 
      aureus and Clinical Characteristics of Different Sites of Infection.
PG  - 1485-1497
LID - 10.2147/IDR.S401998 [doi]
AB  - PURPOSE: Since community-acquired methicillin-resistant Staphylococcus aureus 
      (CA-MRSA) was recognized, the molecular epidemiology of CA-MRSA in China has been 
      diverse. It is unclear whether different sites of CA-MRSA infection differ in 
      antimicrobial resistance and clinical characteristics. The purpose of this study 
      was to identify the molecular types, virulence factors and antimicrobial 
      resistance of CA-MRSA strains and to analyze the clinical characteristics of 
      different sites of CA-MRSA infection. METHODS: 26 CA-MRSA strains were screened 
      from Beijing Chao-Yang Hospital from 2014 to 2022. SCCmec type, MLST type, spa 
      type, Panton-Valentine leukocidin (PVL), hemolysin alpha (Hla), phenolic soluble 
      regulatory protein alpha (PSMalpha), toxic shock syndrome toxin-1 (TSST-1), and 
      enterotoxin (SE) A to E were detected by PCR and gene sequencing. Antimicrobial 
      susceptibility tests and the clinical features of CA-MRSA infection cases were 
      collected for statistical analysis. RESULTS: The predominant type of CA-MRSA was 
      ST59-t437-IV. New non-epidemic types, SCCmec VII, were also found. PVL was seen 
      in 65.4% of CA-MRSA strains and TSST-1 was only be detected in 3.8% of CA-MRSA 
      strain which caused poor prognosis. There were three types of infections: 
      pneumonia (61.5%), infective endocarditis (7.7%), and skin and soft tissue 
      infections (SSTIs) (30.8%). CA-MRSA pneumonia cases were secondary to influenza 
      infection (37.5%). Patients with CA-MRSA-associated infective endocarditis were 
      more likely to have underlying cardiac diseases. Patients with CA-MRSA-associated 
      SSTIs were more likely to have a history of diabetes mellitus, and strains in 
      this group were more susceptible to erythromycin and clindamycin. CONCLUSION: 
      ST59-t437-IV was the primary CA-MRSA type in our research and in China. We 
      proposed that TSST-1 might be one of the indicators to predict the severity and 
      prognosis of CA-MRSA infection. Different sites of CA-MRSA infection had 
      difference in antibiotics susceptibility testing and underlying diseases of 
      patients. It could provide a new perspective on treating different types of 
      CA-MRSA infection.
CI  - (c) 2023 Zhong et al.
FAU - Zhong, Jingjing
AU  - Zhong J
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Wei, Ming
AU  - Wei M
AUID- ORCID: 0000-0003-4035-5060
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Yang, Chunxia
AU  - Yang C
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Yin, Yudong
AU  - Yin Y
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Bai, Yu
AU  - Bai Y
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Li, Ran
AU  - Li R
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
FAU - Gu, Li
AU  - Gu L
AD  - Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of 
      Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230315
PL  - New Zealand
TA  - Infect Drug Resist
JT  - Infection and drug resistance
JID - 101550216
PMC - PMC10024868
OTO - NOTNLM
OT  - Panton-Valentine leukocidin
OT  - antibiotic resistance
OT  - community, acquired methicillin, resistant Staphylococcus aureus
OT  - pneumonia
OT  - staphylococcal chromosomal cassette mec type
COIS- The authors report no conflicts of interest in this work.
EDAT- 2023/03/23 06:00
MHDA- 2023/03/23 06:01
PMCR- 2023/03/15
CRDT- 2023/03/22 01:59
PHST- 2022/12/29 00:00 [received]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/03/22 01:59 [entrez]
PHST- 2023/03/23 06:00 [pubmed]
PHST- 2023/03/23 06:01 [medline]
PHST- 2023/03/15 00:00 [pmc-release]
AID - 401998 [pii]
AID - 10.2147/IDR.S401998 [doi]
PST - epublish
SO  - Infect Drug Resist. 2023 Mar 15;16:1485-1497. doi: 10.2147/IDR.S401998. 
      eCollection 2023.