PMID- 36946508 OWN - NLM STAT- MEDLINE DCOM- 20230517 LR - 20230622 IS - 1096-9071 (Electronic) IS - 0146-6615 (Linking) VI - 95 IP - 4 DP - 2023 Apr TI - SARS-CoV-2 infection alters the gut microbiome in diabetes patients: A cross-sectional study from Bangladesh. PG - e28691 LID - 10.1002/jmv.28691 [doi] AB - Populations of different South Asian nations including Bangladesh reportedly have a high risk of developing diabetes in recent years. This study aimed to investigate the differences in the gut microbiome of COVID-19-positive participants with or without type 2 diabetes mellitus (T2DM) compared with healthy control subjects. Microbiome data of 30 participants with T2DM were compared with 22 age-, sex-, and body mass index (BMI)-matched individuals. Clinical features were recorded while fecal samples were collected aseptically from the participants. Amplicon-based (16S rRNA) metagenome analyses were employed to explore the dysbiosis of gut microbiota and its correlation with genomic and functional features in COVID-19 patients with or without T2DM. Comparing the detected bacterial genera across the sample groups, 98 unique genera were identified, of which 9 genera had unique association with COVID-19 T2DM patients. Among different bacterial groups, Shigella (25%), Bacteroides (23.45%), and Megamonas (15.90%) had higher mean relative abundances in COVID-19 patients with T2DM. An elevated gut microbiota dysbiosis in T2DM patients with COVID-19 was observed while some metabolic functional changes correlated with bidirectional microbiome dysbiosis between diabetes and non-diabetes humans gut were also found. These results further highlight the possible association of COVID-19 infection that might be linked with alteration of gut microbiome among T2DM patients. CI - (c) 2023 Wiley Periodicals LLC. FAU - Mannan, Adnan AU - Mannan A AUID- ORCID: 0000-0003-4070-9586 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Hoque, M Nazmul AU - Hoque MN AUID- ORCID: 0000-0002-4861-0030 AD - Next Generation Sequencing, Research and Innovation laboratory Chittagong (NRICh), Biotechnology Research and Innovation Centre (BRIC), Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. FAU - Noyon, Sajjad Hossain AU - Noyon SH AUID- ORCID: 0000-0001-8613-6571 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Mehedi, H M Hamidullah AU - Mehedi HMH AUID- ORCID: 0000-0001-6683-6773 AD - Department of Gynecology, Obstetrics and Reproductive Health, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh. FAU - Foysal, Md Javed AU - Foysal MJ AUID- ORCID: 0000-0002-2064-8897 AD - Department of Medicine, 250 Bedded General Hospital, Chattogram, Bangladesh. FAU - Salauddin, Asma AU - Salauddin A AUID- ORCID: 0000-0002-5658-8638 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Islam, S M Rafiqul AU - Islam SMR AUID- ORCID: 0000-0001-6901-4070 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Sharmen, Farjana AU - Sharmen F AUID- ORCID: 0000-0003-4611-5519 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Tanni, Afroza Akter AU - Tanni AA AUID- ORCID: 0000-0003-3126-1054 AD - Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh. AD - Department of Endocrinology, Chittagong Medical College, Chattogram, Bangladesh. FAU - Siddiki, Amam Zonaed AU - Siddiki AZ AUID- ORCID: 0000-0003-2990-4022 AD - School of Molecular and Life Sciences, Curtin University, Bentley, WA, Australia. FAU - Tay, Alfred AU - Tay A AD - COVID Diagnostic Lab, Department of Pathology and Parasitology, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh. FAU - Siddique, Md Moradul AU - Siddique MM AD - Helicobacter Research Laboratory, Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia. FAU - Rahman, M Shaminur AU - Rahman MS AD - Department of Computer Science and Engineering, Jashore University of Science and Technology, Jashore, Bangladesh. FAU - Galib, Syed Md AU - Galib SM AD - Helicobacter Research Laboratory, Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia. FAU - Akter, Farhana AU - Akter F AUID- ORCID: 0000-0002-4488-9388 AD - Department of Microbiology, Jashore University of Science and Technology, Jashore, Bangladesh. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 RN - 0 (RNA, Ribosomal, 16S) SB - IM EIN - J Med Virol. 2023 May;95(5):e28828. PMID: 37226969 MH - Humans MH - *Gastrointestinal Microbiome/genetics MH - *Diabetes Mellitus, Type 2/complications MH - Cross-Sectional Studies MH - RNA, Ribosomal, 16S/genetics MH - Dysbiosis/microbiology MH - Bangladesh/epidemiology MH - *COVID-19 MH - SARS-CoV-2/genetics MH - Bacteria/genetics OTO - NOTNLM OT - Bangladesh OT - COVID-19 OT - diabetes OT - gut microbiome OT - metagenome EDAT- 2023/03/23 06:00 MHDA- 2023/05/17 06:42 CRDT- 2023/03/22 08:13 PHST- 2023/03/07 00:00 [revised] PHST- 2023/01/18 00:00 [received] PHST- 2023/03/19 00:00 [accepted] PHST- 2023/05/17 06:42 [medline] PHST- 2023/03/23 06:00 [pubmed] PHST- 2023/03/22 08:13 [entrez] AID - 10.1002/jmv.28691 [doi] PST - ppublish SO - J Med Virol. 2023 Apr;95(4):e28691. doi: 10.1002/jmv.28691.