PMID- 36947266
OWN - NLM
STAT- MEDLINE
DCOM- 20230324
LR  - 20230324
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Mar 22
TI  - Effects of photobiomodulation on oxidative stress in rats with type 2 diabetes 
      mellitus.
PG  - 90
LID - 10.1007/s10103-023-03745-x [doi]
AB  - The present study aimed to evaluate photobiomodulation effects on oxidative 
      stress in type 2 diabetes mellitus (DM2). Thirty-one male Wistar rats were used 
      and divided into 4 groups: group 1 - animals without diabetes mellitus 2 without 
      laser 21 J/cm(2) (C-SHAM), group 2 - animals with diabetes mellitus 2 without 
      laser 21 J/cm(2) (C-DM2), group 3 - animals without diabetes mellitus 2 with 
      laser 21 J/cm(2) (L-SHAM), group 4 - animals with diabetes mellitus 2 with laser 
      21 J/cm(2) (L-DM2). The protocol was performed 5 days/week, for 6 weeks. The 
      animals that received photobiomodulation had one dose irradiated at two spots in 
      the right gastrocnemius muscle. Twenty-four hours after the last intervention, 
      the animals were euthanized. Heart, diaphragm, liver, right gastrocnemius, 
      plasma, kidneys, weighed, and stored for further analysis. In rats with DM2, 
      photobiomodulation promoted a decrease in thiobarbituric acid reactive substance 
      assay (TBARS) in plasma levels. On the other hand, photobiomodulation 
      demonstrated an increase in non-protein thiol levels (NPSH) in the heart, 
      diaphragm and gastrocnemius. Moreover, photobiomodulation produced in the heart, 
      diaphragm and plasma levels led to an increase in superoxide dismutase (SOD). 
      Interestingly, photobiomodulation was able to increase superoxide dismutase in 
      rats without DM2 in the heart, diaphragm, gastrocnemius and kidneys. These 
      findings suggested that 6 weeks of photobiomodulation in rats with DM2 promoted 
      beneficial adaptations in oxidative stress, with a decrease in parameters of 
      oxidant activity and an increase in antioxidant activity.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., 
      part of Springer Nature.
FAU - da Silva Tonetto, Larissa
AU  - da Silva Tonetto L
AD  - Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement 
      and Rehabilitation Sciences, Federal University of Santa Maria, Santa Maria, 
      Brazil.
FAU - da Silva, Carlos Cassiano Figueiro
AU  - da Silva CCF
AD  - Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement 
      and Rehabilitation Sciences, Federal University of Santa Maria, Santa Maria, 
      Brazil.
FAU - Gonzatti, Nubia
AU  - Gonzatti N
AD  - Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement 
      and Rehabilitation Sciences, Federal University of Santa Maria, Santa Maria, 
      Brazil.
FAU - Guex, Camille Gaube
AU  - Guex CG
AD  - Department of Physiology and Pharmacology, Federal University of Santa Maria, 
      Santa Maria, RS, Brazil.
FAU - Hartmann, Diane Duarte
AU  - Hartmann DD
AD  - Department of Biochemical Sciences, Postgraduate Program in Toxicological 
      Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil.
FAU - Boschi, Emerson Soldateli
AU  - Boschi ES
AD  - Department of Physiotherapy, Pontifical Catholic University of Rio Grande Do Sul, 
      Porto Alegre, RS, Brazil.
FAU - Lago, Pedro Dal
AU  - Lago PD
AD  - Department of Physiotherapy, Federal University of Health Sciences, Porto Alegre, 
      RS, Brazil.
FAU - Trevisan, Maria Elaine
AU  - Trevisan ME
AD  - Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement 
      and Rehabilitation Sciences, Federal University of Santa Maria, Santa Maria, 
      Brazil.
FAU - de Freitas Bauermann, Liliane
AU  - de Freitas Bauermann L
AD  - Department of Physiology and Pharmacology, Federal University of Santa Maria, 
      Santa Maria, RS, Brazil.
FAU - Jaenisch, Rodrigo Boemo
AU  - Jaenisch RB
AD  - Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement 
      and Rehabilitation Sciences, Federal University of Santa Maria, Santa Maria, 
      Brazil. rbjaenisch@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230322
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - Rats, Wistar
MH  - *Diabetes Mellitus, Type 2/radiotherapy
MH  - *Diabetes Mellitus, Experimental/radiotherapy
MH  - Oxidative Stress
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances
OTO - NOTNLM
OT  - Antioxidant activity
OT  - Oxidative activity
OT  - Photobiomodulation
EDAT- 2023/03/23 06:00
MHDA- 2023/03/25 06:00
CRDT- 2023/03/22 12:17
PHST- 2022/01/26 00:00 [received]
PHST- 2023/02/18 00:00 [accepted]
PHST- 2023/03/22 12:17 [entrez]
PHST- 2023/03/23 06:00 [pubmed]
PHST- 2023/03/25 06:00 [medline]
AID - 10.1007/s10103-023-03745-x [pii]
AID - 10.1007/s10103-023-03745-x [doi]
PST - epublish
SO  - Lasers Med Sci. 2023 Mar 22;38(1):90. doi: 10.1007/s10103-023-03745-x.