PMID- 36949244
OWN - NLM
STAT- MEDLINE
DCOM- 20230524
LR  - 20230529
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 20
IP  - 5
DP  - 2023 May
TI  - Dendritic cell subsets in cancer immunity and tumor antigen sensing.
PG  - 432-447
LID - 10.1038/s41423-023-00990-6 [doi]
AB  - Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play 
      crucial roles in both innate and adaptive immune responses. Due to their ability 
      to cross-present tumor cell-associated antigens to naive T cells, DCs are 
      instrumental in the generation of specific T-cell-mediated antitumor effector 
      responses in the control of tumor growth and tumor cell dissemination. Within an 
      immunosuppressive tumor microenvironment, DC antitumor functions can, however, be 
      severely impaired. In this review, we focus on the mechanisms of DC capture and 
      activation by tumor cell antigens and the role of the tumor microenvironment in 
      shaping DC functions, taking advantage of recent studies showing the phenotype 
      acquisition, transcriptional state and functional programs revealed by scRNA-seq 
      analysis. The therapeutic potential of DC-mediated tumor antigen sensing in 
      priming antitumor immunity is also discussed.
CI  - (c) 2023. The Author(s).
FAU - Del Prete, Annalisa
AU  - Del Prete A
AUID- ORCID: 0000-0002-3738-412X
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
AD  - Humanitas Clinical and Research Center-IRCCS Rozzano, Milano, Italy.
FAU - Salvi, Valentina
AU  - Salvi V
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
FAU - Soriani, Alessandra
AU  - Soriani A
AD  - Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 
      Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
FAU - Laffranchi, Mattia
AU  - Laffranchi M
AD  - Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 
      Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
FAU - Sozio, Francesca
AU  - Sozio F
AD  - Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 
      Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
FAU - Bosisio, Daniela
AU  - Bosisio D
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
FAU - Sozzani, Silvano
AU  - Sozzani S
AD  - Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 
      Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. 
      silvano.sozzani@uniroma1.it.
AD  - IRCCS Neuromed, Pozzilli, IS, Italy. silvano.sozzani@uniroma1.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230322
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Humans
MH  - *Dendritic Cells
MH  - *Neoplasms
MH  - Antigens, Neoplasm
MH  - T-Lymphocytes
MH  - Tumor Microenvironment
PMC - PMC10203372
OTO - NOTNLM
OT  - Dendritic cell subsets
OT  - Immune cell death
OT  - Innate immune sensing
OT  - Migration
OT  - Tumor microenvironment
OT  - Tumor-derived extracellular vesicles
COIS- The authors declare no competing interests.
EDAT- 2023/03/24 06:00
MHDA- 2023/05/24 06:42
PMCR- 2023/03/22
CRDT- 2023/03/23 00:23
PHST- 2022/11/11 00:00 [received]
PHST- 2023/02/14 00:00 [accepted]
PHST- 2023/05/24 06:42 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 00:23 [entrez]
PHST- 2023/03/22 00:00 [pmc-release]
AID - 10.1038/s41423-023-00990-6 [pii]
AID - 990 [pii]
AID - 10.1038/s41423-023-00990-6 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2023 May;20(5):432-447. doi: 10.1038/s41423-023-00990-6. Epub 
      2023 Mar 22.