PMID- 36949249
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 273
IP  - 8
DP  - 2023 Dec
TI  - Differences in olfactory dysfunction and its relationship with cognitive function 
      in schizophrenia patients with and without auditory verbal hallucinations.
PG  - 1813-1824
LID - 10.1007/s00406-023-01589-8 [doi]
AB  - Olfactory discrimination dysfunction has been observed in patients with 
      schizophrenia (SCZ), but its relationship with cognitive function has not been 
      clarified. The purpose of this study was to examine the differences in olfactory 
      identification function in SCZ patients with and without auditory verbal 
      hallucinations (AVHs) and its relationship with cognitive function. Olfactory 
      identification function was measured in 80 SCZ patients with AVHs, 57 SCZ 
      patients without AVHs, and 87 healthy controls (HC). Clinical symptom scores and 
      neuropsychological measures were also administered to all corresponding subjects. 
      Compared to HC, SCZ patients showed significant deficits in olfactory 
      identification and cognitive function, but there were no differences in olfactory 
      identification dysfunction and cognitive dysfunction between the two subgroups. 
      In the non-AVHs subgroup only, poorer Olfactory Stick Identification Test for 
      Japanese (OSIT-J) scores were significantly and positively correlated with total 
      and delayed recall (Bonferroni correction, p < 0.002). Stepwise regression 
      analysis revealed that factors affecting olfactory identification impairment 
      differed in the two SCZ patient subgroups. In conclusion, this study highlights 
      the commonality of olfactory identification dysfunction in SCZ patients and the 
      importance of olfactory assessment of different subtypes of SCZ patients.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Wang, Qianjin
AU  - Wang Q
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Ren, Honghong
AU  - Ren H
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
AD  - Shandong Provincial Hospital Affiliated to Shandong First Medical University, 
      Shandong, China.
FAU - Li, Zongchang
AU  - Li Z
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Li, Jinguang
AU  - Li J
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Dai, Lulin
AU  - Dai L
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Dong, Min
AU  - Dong M
AD  - Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, Guangdong, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - He, Jingqi
AU  - He J
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Chen, Xiaogang
AU  - Chen X
AUID- ORCID: 0000-0002-3706-1697
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Gu, Lin
AU  - Gu L
AD  - RIKEN AIP, Tokyo, Japan.
FAU - He, Ying
AU  - He Y
AUID- ORCID: 0000-0001-8667-3107
AD  - Department of Psychiatry, and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      Hunan, China. yinghe@csu.edu.cn.
FAU - Tang, Jinsong
AU  - Tang J
AUID- ORCID: 0000-0003-3796-1377
AD  - Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, 310016, China. tangjinsong@zju.edu.cn.
LA  - eng
GR  - 82171495/National Natural Science Foundation of China/
GR  - 81871057/National Natural Science Foundation of China/
GR  - 81871056/National Natural Science Foundation of China/
GR  - CX20220341/Hunan Provincial Innovation Foundation for Postgraduate/
GR  - 2022ZZTS0259/Fundamental Research Funds for Central Universities of the Central 
      South University/
PT  - Journal Article
DEP - 20230322
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Humans
MH  - *Schizophrenia
MH  - Hallucinations
MH  - Cognition
MH  - *Olfaction Disorders/etiology
OTO - NOTNLM
OT  - Auditory verbal hallucinations
OT  - Olfactory identification dysfunction
OT  - Schizophrenia
EDAT- 2023/03/24 06:00
MHDA- 2023/12/17 09:44
CRDT- 2023/03/23 00:24
PHST- 2022/10/18 00:00 [received]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 00:24 [entrez]
AID - 10.1007/s00406-023-01589-8 [pii]
AID - 10.1007/s00406-023-01589-8 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2023 Dec;273(8):1813-1824. doi: 
      10.1007/s00406-023-01589-8. Epub 2023 Mar 22.