PMID- 36949420
OWN - NLM
STAT- MEDLINE
DCOM- 20230324
LR  - 20230410
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 22
TI  - Performance of heart rate adjusted heart rate variability for risk stratification 
      of sudden cardiac death.
PG  - 144
LID - 10.1186/s12872-023-03184-0 [doi]
LID - 144
AB  - PURPOSE: As a non-invasive tool for the assessment of cardiovascular autonomic 
      function, the predictive value of heart rate variability (HRV) for sudden cardiac 
      death (SCD) risk stratification remains unclear. In this study, we investigated 
      the performance of the individualized heart rate (HR) adjusted HRV (HRV(I)) for 
      SCD risk stratification in subjects with diverse risks. METHODS: A total of 11 
      commonly used HRV metrics were analyzed in 192 subjects, including 88 healthy 
      controls (low risk group), 82 hypertrophic cardiomyopathy (HCM) patients (medium 
      risk group), and 22 SCD victims (high risk group). The relationship between HRV 
      metrics and HR was examined with long-term and short-term analysis. The 
      performance HRV(I) was evaluated by area under the receiver operating 
      characteristic curve (AUC) and covariance of variation (CV). RESULTS: Most of the 
      HRV metrics were exponentially decayed with the increase of HR, while the 
      exponential power coefficients were significantly different among groups. The 
      HRV(I) metrics discriminated low, medium and high risk subjects with a median AUC 
      of 0.72[0.11], which was considerably higher than that of the traditional 
      long-term (0.63[0.04]) and short-term (0.58[0.05]) HRV without adjustment. The 
      average CV of the HRV(I) metrics was also significantly lower than traditional 
      short-term HRV metrics (0.09 +/- 0.02 vs. 0.24 +/- 0.13, p < 0.01). CONCLUSIONS: 
      Subjects with diverse risks of SCD had similar exponential decay relationship 
      between HRV metrics and HR, but with different decaying rates. HRV(I) provides 
      reliable and robust estimation for risk stratification of SCD.
CI  - (c) 2023. The Author(s).
FAU - Yan, Su-Peng
AU  - Yan SP
AD  - Department of Biomedical Engineering and Imaging Medicine, Army Medical 
      University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
FAU - Song, Xin
AU  - Song X
AD  - Department of Biomedical Engineering and Imaging Medicine, Army Medical 
      University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
FAU - Wei, Liang
AU  - Wei L
AD  - Department of Biomedical Engineering and Imaging Medicine, Army Medical 
      University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
FAU - Gong, Yu-Shun
AU  - Gong YS
AD  - Department of Biomedical Engineering and Imaging Medicine, Army Medical 
      University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
FAU - Hu, Hou-Yuan
AU  - Hu HY
AD  - Department of Cardiology, Southwest Hospital, Army Medical University, Chongqing, 
      400038, China.
FAU - Li, Yong-Qin
AU  - Li YQ
AD  - Department of Biomedical Engineering and Imaging Medicine, Army Medical 
      University, 30 Gaotanyan Main Street, Chongqing, 400038, China. 
      leeoken@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230322
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Humans
MH  - Heart Rate/physiology
MH  - *Death, Sudden, Cardiac/etiology
MH  - Heart
MH  - Risk Factors
MH  - *Cardiomyopathy, Hypertrophic
MH  - Risk Assessment
PMC - PMC10032001
OTO - NOTNLM
OT  - Heart rate
OT  - Heart rate variability
OT  - Hypertrophic cardiomyopathy
OT  - Risk stratification
OT  - Sudden cardiac death
COIS- The authors declare no competing interests.
EDAT- 2023/03/24 06:00
MHDA- 2023/03/25 06:00
PMCR- 2023/03/22
CRDT- 2023/03/23 00:32
PHST- 2022/12/02 00:00 [received]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/03/23 00:32 [entrez]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/25 06:00 [medline]
PHST- 2023/03/22 00:00 [pmc-release]
AID - 10.1186/s12872-023-03184-0 [pii]
AID - 3184 [pii]
AID - 10.1186/s12872-023-03184-0 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2023 Mar 22;23(1):144. doi: 10.1186/s12872-023-03184-0.