PMID- 36949617
OWN - NLM
STAT- MEDLINE
DCOM- 20240307
LR  - 20240418
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 30
IP  - 3
DP  - 2024 Mar
TI  - Abnormal characteristic static and dynamic functional network connectivity in 
      idiopathic normal pressure hydrocephalus.
PG  - e14178
LID - 10.1111/cns.14178 [doi]
LID - e14178
AB  - AIMS: Idiopathic Normal pressure hydrocephalus (iNPH) is a neurodegenerative 
      disease characterized by gait disturbance, dementia, and urinary dysfunction. The 
      neural network mechanisms underlying this phenomenon is currently unknown. 
      METHODS: To investigate the resting-state functional connectivity (rs-FC) 
      abnormalities of iNPH-related brain connectivity from static and dynamic 
      perspectives and the correlation of these abnormalities with clinical symptoms 
      before and 3-month after shunt. We investigated both static and dynamic 
      functional network connectivity (sFNC and dFNC, respectively) in 33 iNPH patients 
      and 23 healthy controls (HCs). RESULTS: The sFNC and dFNC of networks were 
      generally decreased in iNPH patients. The reduction in sFNC within the default 
      mode network (DMN) and between the somatomotor network (SMN) and visual network 
      (VN) were related to symptoms. The temporal properties of dFNC and its temporal 
      variability in state-4 were sensitive to the identification of iNPH and were 
      correlated with symptoms. The temporal variability in the dorsal attention 
      network (DAN) increased, and the average instantaneous FC was altered among 
      networks in iNPH. These features were partially associated with clinical 
      symptoms. CONCLUSION: The dFNC may be a more sensitive biomarker for altered 
      network function in iNPH, providing us with extra information on the mechanisms 
      of iNPH.
CI  - (c) 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & 
      Sons Ltd.
FAU - Huang, Wenjun
AU  - Huang W
AD  - Department of Radiology, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Fang, Xuhao
AU  - Fang X
AD  - Department of Neurosurgery, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Li, Shihong
AU  - Li S
AD  - Department of Radiology, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Mao, Renling
AU  - Mao R
AD  - Department of Neurosurgery, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Ye, Chuntao
AU  - Ye C
AD  - Department of Radiology, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Radiology, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Deng, Yao
AU  - Deng Y
AD  - Department of Neurosurgery, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Lin, Guangwu
AU  - Lin G
AUID- ORCID: 0000-0001-5085-2111
AD  - Department of Radiology, Huadong Hospital Affiliated to Fudan University, 
      Shanghai, China.
LA  - eng
GR  - HDLC2022003/Investigator-Initiated Research Projects of Huadong Hospital/
GR  - 81771816/National Natural Science Foundation of China/
GR  - SHDC2022DRT025/Shanghai Hospital Development Center/
GR  - SKLY2022CRT402/Shanghai Hospital Development Center/
GR  - 201740003/Shanghai Municipal Population and Family Planning Commission/
GR  - 202240257/Shanghai Municipal Population and Family Planning Commission/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230322
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
SB  - IM
MH  - Humans
MH  - *Hydrocephalus, Normal Pressure/diagnostic imaging
MH  - *Neurodegenerative Diseases
MH  - Brain/diagnostic imaging
MH  - *Movement Disorders
MH  - Head
MH  - Magnetic Resonance Imaging
MH  - Brain Mapping
PMC - PMC10915979
OTO - NOTNLM
OT  - dynamic
OT  - functional network connectivity
OT  - idiopathic normal pressure hydrocephalus
OT  - independent component analysis
OT  - resting-state functional magnetic resonance imaging
OT  - static
COIS- None of the authors has any conflicts of interest to disclosure.
EDAT- 2023/03/24 06:00
MHDA- 2024/03/07 06:43
PMCR- 2023/03/22
CRDT- 2023/03/23 01:13
PHST- 2023/03/02 00:00 [revised]
PHST- 2022/11/22 00:00 [received]
PHST- 2023/03/03 00:00 [accepted]
PHST- 2024/03/07 06:43 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 01:13 [entrez]
PHST- 2023/03/22 00:00 [pmc-release]
AID - CNS14178 [pii]
AID - 10.1111/cns.14178 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2024 Mar;30(3):e14178. doi: 10.1111/cns.14178. Epub 2023 Mar 
      22.