PMID- 36950089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230324
IS  - 1759-720X (Print)
IS  - 1759-7218 (Electronic)
IS  - 1759-720X (Linking)
VI  - 15
DP  - 2023
TI  - Comparison of clinical efficiency between intra-articular injection of 
      platelet-rich plasma and hyaluronic acid for osteoarthritis: a meta-analysis of 
      randomized controlled trials.
PG  - 1759720X231157043
LID - 10.1177/1759720X231157043 [doi]
LID - 1759720X231157043
AB  - BACKGROUND: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are non-surgical 
      treatments for osteoarthritis (OA), but the comparison of their efficiency is 
      still inconclusive. OBJECTIVES: The objectives of this study were to compare the 
      efficacy of PRP and HA in the treatment of OA by meta-analysis and to explore the 
      effects of different injection times and leukocyte concentration on the efficacy 
      of PRP. DESIGN: Meta-analysis and subgroup analysis were conducted. The data were 
      analyzed by Review Manager v5.4.1. DATA SOURCES AND METHODS: Articles were 
      retrieved and screened from PubMed, the Cochrane Library, Web of Science, and 
      Embase. The outcome included the total Western Ontario and McMaster Universities 
      Osteoarthritis Index (WOMAC), the visual analog scale (VAS), adverse events 
      (AEs), the International Knee Documentation Committee (IKDC), and the 
      satisfaction rate. RESULTS: A total of 30 articles involving 2733 patients were 
      included. The total WOMAC score and IKDC score of the PRP group were better than 
      those of the HA group at the last follow-up time, while there was no significant 
      difference in AEs, satisfaction rate, and VAS between the two groups. In our 
      subgroup analysis, there was no significant difference between single-injection 
      PRP and triple-injection PRP. Leukocyte-poor PRP (LP-PRP) was better than 
      leukocyte-rich PRP (LR-PRP) in IKDC, but there was no significant difference 
      between them in the other scores. CONCLUSIONS: In the treatment of OA, compared 
      with HA, PRP performed better in the improvement of the patient's function. There 
      was no significant difference in VAS and AEs between the two groups, and the 
      safety was comparable. LP-PRP looked to be superior to LR-PRP in functional 
      recovery, but there appeared to be no significant difference in pain relief 
      between them. There was no significant difference between single PRP and triple 
      PRP in the subgroup analysis.
CI  - (c) The Author(s), 2023.
FAU - Chen, Lili
AU  - Chen L
AUID- ORCID: 0000-0002-8572-9663
AD  - Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Jin, Shirong
AU  - Jin S
AUID- ORCID: 0000-0002-1862-4677
AD  - Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Yao, Yunheng
AU  - Yao Y
AUID- ORCID: 0000-0002-7279-6306
AD  - Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - He, Sixian
AU  - He S
AUID- ORCID: 0000-0002-7543-6613
AD  - Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - He, Jinshen
AU  - He J
AUID- ORCID: 0000-0003-0277-3819
AD  - Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South 
      University, Changsha 410013, China.
LA  - eng
PT  - Address
DEP - 20230317
PL  - England
TA  - Ther Adv Musculoskelet Dis
JT  - Therapeutic advances in musculoskeletal disease
JID - 101517322
PMC - PMC10026092
OTO - NOTNLM
OT  - hyaluronic acid
OT  - intra-articular injection
OT  - meta-analysis
OT  - osteoarthritis
OT  - platelet-rich plasma
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/03/24 06:00
MHDA- 2023/03/24 06:01
PMCR- 2023/03/17
CRDT- 2023/03/23 02:20
PHST- 2022/08/14 00:00 [received]
PHST- 2023/01/27 00:00 [accepted]
PHST- 2023/03/23 02:20 [entrez]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/24 06:01 [medline]
PHST- 2023/03/17 00:00 [pmc-release]
AID - 10.1177_1759720X231157043 [pii]
AID - 10.1177/1759720X231157043 [doi]
PST - epublish
SO  - Ther Adv Musculoskelet Dis. 2023 Mar 17;15:1759720X231157043. doi: 
      10.1177/1759720X231157043. eCollection 2023.