PMID- 36950975
OWN - NLM
STAT- MEDLINE
DCOM- 20230413
LR  - 20230413
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Linking)
VI  - 59
IP  - 30
DP  - 2023 Apr 11
TI  - Colorectal cancer therapy mediated by nanomedicines.
PG  - 4423-4435
LID - 10.1039/d2cc06212g [doi]
AB  - Colorectal cancer is the third most malignant gastrointestinal tumor. Although 
      traditional chemotherapy and radiotherapy have been widely used for treating 
      colorectal cancer, the treatment effect is still unsatisfactory, resulting in a 
      high mortality rate and a low 5-year survival rate. In recent years, with the 
      development of molecular biology of colorectal cancer, many promising therapeutic 
      strategies based on nanomaterials have been developed for colorectal cancer. In 
      this review, we focus on recent advances in colorectal cancer treatment-related 
      nanomedicines. We first discuss the exploration of stimuli-responsive drug 
      delivery systems (DDSs) for colorectal cancer treatment using pH, hypoxia, 
      glutathione (GSH), enzymes, light, magnetic fields (MF), and ultrasound (US) as 
      stimuli. Moreover, the latest progress in emerging therapy for colorectal cancer 
      is further summarized, including photothermal therapy (PTT), magnetothermal 
      therapy (MTT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and 
      chemodynamic therapy (CDT). Finally, we explore the existing challenges and 
      future directions for the better design and development of nanomedicines for 
      clinical colorectal cancer treatment.
FAU - Zhang, Shaopeng
AU  - Zhang S
AD  - Department of Gastric and Colorectal Surgery, General Surgery Center, The First 
      Hospital of Jilin University, Changchun 130021, China.
FAU - Zhang, Hao
AU  - Zhang H
AD  - State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of 
      Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, P. 
      R. China. yhwang@ciac.ac.cn.
FAU - Song, Peizhe
AU  - Song P
AD  - Department of Gastric and Colorectal Surgery, General Surgery Center, The First 
      Hospital of Jilin University, Changchun 130021, China.
FAU - Wang, Daguang
AU  - Wang D
AD  - Department of Gastric and Colorectal Surgery, General Surgery Center, The First 
      Hospital of Jilin University, Changchun 130021, China.
FAU - Wang, Yinghui
AU  - Wang Y
AUID- ORCID: 0000-0001-7305-5852
AD  - State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of 
      Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, P. 
      R. China. yhwang@ciac.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230411
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
SB  - IM
MH  - Humans
MH  - Nanomedicine
MH  - *Photochemotherapy/methods
MH  - *Hyperthermia, Induced
MH  - *Nanostructures
MH  - *Colorectal Neoplasms
EDAT- 2023/03/24 06:00
MHDA- 2023/04/13 06:43
CRDT- 2023/03/23 04:43
PHST- 2023/04/13 06:43 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 04:43 [entrez]
AID - 10.1039/d2cc06212g [doi]
PST - epublish
SO  - Chem Commun (Camb). 2023 Apr 11;59(30):4423-4435. doi: 10.1039/d2cc06212g.