PMID- 36952158
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 22
DP  - 2023 May
TI  - Association between co-exposure of polycyclic aromatic hydrocarbons and chronic 
      obstructive pulmonary disease among the US adults: results from the 2013-2016 
      National Health and Nutrition Examination Survey.
PG  - 62981-62992
LID - 10.1007/s11356-023-26413-7 [doi]
AB  - Although existing epidemiological studies have reported the relationship between 
      single polycyclic aromatic hydrocarbon (PAH) exposure and chronic obstructive 
      pulmonary disease (COPD), little is known about the impact of PAH mixture 
      exposure on COPD. Therefore, we aimed to evaluate the associations of single and 
      mixed exposures to PAHs with COPD in US adults using data from NHANES 2013-2016 
      by fitting three statistical methods, including multiple logistic regression, 
      Bayesian kernel machine regression (BKMR), and quantile-based g-computation 
      (qgcomp) models. This study included 1836 participants aged 40 and older. 
      Multiple logistic regression showed that 2-FLU, 1-PHE, 1-PYR, and 2&3-PHE 
      increased the risk of COPD after adjusting for all covariates. The BKMR model 
      identified positive trends between PAH mixture and the risk of COPD in all adults 
      and males when all PAHs were at or above their 55th percentile compared to all 
      PAHs at their 50th percentile. The qgcomp model suggested that PAH co-exposure 
      increased the risk of COPD (OR:1.44, 95%CI:1.09, 1.90) when each quartile 
      increased in PAH mixture concentration, with 2-FLU having the highest weight. The 
      combined impact also be observed in men. In conclusion, PAHs co-exposure was 
      associated with a higher risk of COPD, especially in males, with the positive 
      impact of 2-FLU being the most important.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wen, Lin
AU  - Wen L
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Ben, Xiaosong
AU  - Ben X
AD  - Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, 510080, China.
FAU - Yang, Zhiyu
AU  - Yang Z
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wu, Yingying
AU  - Wu Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Tan, Yuxuan
AU  - Tan Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Li, Yexin
AU  - Li Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wu, Xiaomei
AU  - Wu X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liu, Shan
AU  - Liu S
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Weng, Xueqiong
AU  - Weng X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Tian, Dan
AU  - Tian D
AD  - Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, 510080, China.
FAU - Jing, Chunxia
AU  - Jing C
AUID- ORCID: 0000-0001-7333-4181
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China. 
      jcxphd@gmail.com.
AD  - Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 
      Guangzhou, 510632, Guangdong, China. jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230323
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Male
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - *Polycyclic Aromatic Hydrocarbons
MH  - Bayes Theorem
MH  - *Pulmonary Disease, Chronic Obstructive/chemically induced/epidemiology
MH  - Logistic Models
MH  - Biomarkers
OTO - NOTNLM
OT  - BKMR
OT  - Chronic obstructive pulmonary disease (COPD)
OT  - Co-exposure
OT  - Polycyclic aromatic hydrocarbons (PAHs)
OT  - Sex differences
OT  - qgcomp
EDAT- 2023/03/24 06:00
MHDA- 2023/05/10 06:42
CRDT- 2023/03/23 12:23
PHST- 2022/10/18 00:00 [received]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 12:23 [entrez]
AID - 10.1007/s11356-023-26413-7 [pii]
AID - 10.1007/s11356-023-26413-7 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 May;30(22):62981-62992. doi: 
      10.1007/s11356-023-26413-7. Epub 2023 Mar 23.