PMID- 36958254
OWN - NLM
STAT- MEDLINE
DCOM- 20230412
LR  - 20240423
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 105
DP  - 2023 May
TI  - Narcolepsy is associated with an increased risk of HLA-related autoimmune 
      diseases: Evidence from a nationwide healthcare system data in South Korea.
PG  - 37-42
LID - S1389-9457(23)00093-X [pii]
LID - 10.1016/j.sleep.2023.03.006 [doi]
AB  - STUDY OBJECTIVES: To determine the incidence rate of narcolepsy in South Korea 
      and closely examine the relationship between narcolepsy, which is believed to be 
      an autoimmune response, and other systemic autoimmune diseases. METHODS: We 
      examined data from the South Korean nationwide health insurance claims database 
      from 2010 to 2019. Our study included patients with narcolepsy as well as age- 
      and sex-matched controls without narcolepsy. We estimated the incidence of 
      narcolepsy and the odds ratio of narcolepsy and associated autoimmune 
      comorbidities in South Korea. RESULTS: We identified 8710 patients with 
      narcolepsy (59.8% men and 40.2% women). The incidence of narcolepsy was 0.05%. 
      Patients with narcolepsy were at a significantly high risk of ankylosing 
      spondylitis, rheumatoid arthritis, and Sjogren's syndrome, which diseases are 
      known to be related to human leukocyte antigen (HLA) genes. CONCLUSIONS: 
      Narcolepsy is closely related to systemic autoimmune diseases, particularly those 
      related to HLA genes.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Oh, Jihye
AU  - Oh J
AD  - Department of Psychiatry, College of Medicine, The Catholic University of Korea, 
      South Korea.
FAU - Cho, Eunhae
AU  - Cho E
AD  - Department of Colorectal Surgery, Seoul Asan Medical Center, Ulsan University, 
      South Korea.
FAU - Um, Yoo-Hyun
AU  - Um YH
AD  - Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The 
      Catholic University of Korea, South Korea.
FAU - Oh, Sei Hoon
AU  - Oh SH
AD  - Department of Environmental Horticulture, College of Natural Science, The 
      University of Seoul, South Korea.
FAU - Hong, Seung-Chul
AU  - Hong SC
AD  - Department of Psychiatry, College of Medicine, The Catholic University of Korea, 
      South Korea; Department of Psychiatry, St. Vincent's Hospital, College of 
      Medicine, The Catholic University of Korea, South Korea. Electronic address: 
      hscjohn@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230311
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
MH  - Arthritis, Rheumatoid/epidemiology/genetics
MH  - *Autoimmune Diseases/epidemiology/genetics
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Databases, Factual
MH  - Genetic Predisposition to Disease
MH  - *HLA Antigens/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - Incidence
MH  - *Insurance Claim Reporting/statistics & numerical data
MH  - *Narcolepsy/epidemiology/genetics
MH  - Odds Ratio
MH  - Republic of Korea/epidemiology
MH  - Sjogren's Syndrome/epidemiology/genetics
MH  - Spondylitis, Ankylosing/epidemiology/genetics
OTO - NOTNLM
OT  - Human leukocyte antigen
OT  - Narcolepsy
OT  - Systemic rheumatoid disease
EDAT- 2023/03/24 06:00
MHDA- 2023/04/12 06:41
CRDT- 2023/03/23 19:10
PHST- 2022/10/27 00:00 [received]
PHST- 2023/01/27 00:00 [revised]
PHST- 2023/03/05 00:00 [accepted]
PHST- 2023/04/12 06:41 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 19:10 [entrez]
AID - S1389-9457(23)00093-X [pii]
AID - 10.1016/j.sleep.2023.03.006 [doi]
PST - ppublish
SO  - Sleep Med. 2023 May;105:37-42. doi: 10.1016/j.sleep.2023.03.006. Epub 2023 Mar 
      11.