PMID- 36958266
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230414
IS  - 1768-3254 (Electronic)
IS  - 0223-5234 (Linking)
VI  - 252
DP  - 2023 Apr 5
TI  - Recent advances in the development of methyltransferase (MTase) inhibitors 
      against (re)emerging arboviruses diseases dengue and Zika.
PG  - 115290
LID - S0223-5234(23)00256-8 [pii]
LID - 10.1016/j.ejmech.2023.115290 [doi]
AB  - Emerging and/or re-emerging viral diseases such as dengue and Zika are a 
      worldwide concern. Therefore, new antiviral therapeutics are necessary. In this 
      sense, a non-structural protein with methyltransferase (MTase) activity is an 
      attractive drug target because it plays a crucial role in dengue and Zika virus 
      replication. Different drug strategies such as virtual screening, molecular 
      docking, and molecular dynamics have identified new inhibitors that bind on the 
      MTase active site. Therefore, in this review, we analyze MTase inhibitors, 
      including S-adenosyl-L-methionine (SAM), S-adenosyl-l-homocysteine (SAH) and 
      guanosine-5'-triphosphate (GTP) analogs, nitrogen-containing heterocycles 
      (pyrimidine, adenosine, and pyridine), urea derivatives, and natural products. 
      Advances in the design of MTase inhibitors could lead to the optimization of a 
      possible single or broad-spectrum antiviral drug against dengue and Zika virus.
CI  - Copyright (c) 2023 Elsevier Masson SAS. All rights reserved.
FAU - Delgado-Maldonado, Timoteo
AU  - Delgado-Maldonado T
AD  - Laboratorio de Biotecnologia Farmaceutica, Centro de Biotecnologia Genomica, 
      Instituto Politecnico Nacional, 88710, Reynosa, Mexico.
FAU - Moreno-Herrera, Antonio
AU  - Moreno-Herrera A
AD  - Laboratorio de Biotecnologia Farmaceutica, Centro de Biotecnologia Genomica, 
      Instituto Politecnico Nacional, 88710, Reynosa, Mexico.
FAU - Pujadas, Gerard
AU  - Pujadas G
AD  - Departament de Bioquimica i Biotecnologia, Research group in Cheminformatics & 
      Nutrition, Campus de Sescelades, Universitat Rovira i Virgili, 43007, Tarragona, 
      Catalonia, Spain.
FAU - Vazquez-Jimenez, Lenci K
AU  - Vazquez-Jimenez LK
AD  - Laboratorio de Biotecnologia Farmaceutica, Centro de Biotecnologia Genomica, 
      Instituto Politecnico Nacional, 88710, Reynosa, Mexico.
FAU - Gonzalez-Gonzalez, Alonzo
AU  - Gonzalez-Gonzalez A
AD  - Laboratorio de Biotecnologia Farmaceutica, Centro de Biotecnologia Genomica, 
      Instituto Politecnico Nacional, 88710, Reynosa, Mexico.
FAU - Rivera, Gildardo
AU  - Rivera G
AD  - Laboratorio de Biotecnologia Farmaceutica, Centro de Biotecnologia Genomica, 
      Instituto Politecnico Nacional, 88710, Reynosa, Mexico. Electronic address: 
      gildardors@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230320
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Viral Nonstructural Proteins)
RN  - 0 (Antiviral Agents)
RN  - EC 2.1.1.- (Methyltransferases)
SB  - IM
MH  - Humans
MH  - *Zika Virus
MH  - Molecular Docking Simulation
MH  - *Arboviruses/metabolism
MH  - Viral Nonstructural Proteins
MH  - Antiviral Agents/chemistry
MH  - Methyltransferases
MH  - *Dengue/drug therapy
MH  - *Zika Virus Infection/drug therapy
OTO - NOTNLM
OT  - Dengue
OT  - Drug treatment
OT  - Inhibitors
OT  - Methyltransferase
OT  - Mosquito-borne viruses
OT  - Re-emerging viral diseases
OT  - Zika
COIS- Declaration of competing interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Gildardo Rivera reports financial support was provided by Secretaria 
      de Investigacion y Posgrado, Instituto Politecnico Nacional. Antonio 
      moreno-herrera reports a relationship with AstraZeneca Pharmaceuticals LP that 
      includes: employment. None.
EDAT- 2023/03/24 06:00
MHDA- 2023/04/14 06:42
CRDT- 2023/03/23 19:10
PHST- 2022/11/23 00:00 [received]
PHST- 2023/03/14 00:00 [revised]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/04/14 06:42 [medline]
PHST- 2023/03/24 06:00 [pubmed]
PHST- 2023/03/23 19:10 [entrez]
AID - S0223-5234(23)00256-8 [pii]
AID - 10.1016/j.ejmech.2023.115290 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2023 Apr 5;252:115290. doi: 10.1016/j.ejmech.2023.115290. Epub 
      2023 Mar 20.