PMID- 36960149
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230325
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 14
DP  - 2023
TI  - Sex hormone-mediated change on muscle activation deactivation dynamics in young 
      eumenorrheic women.
PG  - 1104578
LID - 10.3389/fphys.2023.1104578 [doi]
LID - 1104578
AB  - The goal of the study was to characterize muscle activation/deactivation dynamics 
      across the menstrual cycle in healthy young women. Twenty-two healthy 
      eumenorrheic women (age: 27.0 +/- 4.4 years; mean +/- SD) were tested every other day 
      for one menstrual cycle. Serum estradiol and progesterone were quantified at the 
      time of testing. Peak torque (PT), time to peak torque (TPT), and half relaxation 
      time (HRT) of soleus muscle twitch were measured. Muscle twitch was elicited by 
      delivering 1 ms width electrical pulses to the tibial nerve at an intensity that 
      generated a maximum motor response (S-100) and at supramaximal intensity (S-120; 
      1.2 x S-100). The analyses were performed for each menstrual cycle phase: 1) the 
      follicular phase to analyze the effect of estradiol while the progesterone 
      concentrations remained at low concentrations; 2) the luteal phase to analyze the 
      effect of progesterone with background estradiol concentrations. In the 
      follicular phase, there was no association of estradiol for PT, TPT, and HRT. In 
      the luteal phase, while estradiol had no association on PT, TPT, and HRT, 
      progesterone expressed a significant association with HRT reduction but no 
      association on PT or TPT. Also, there was a significant estradiol and 
      progesterone interaction for HRT. However, the regression parameters are nearly 
      zero, suggesting that the change in HRT may not have an impact on muscle 
      performance across the menstrual cycle but implications on other women's health 
      conditions with elevated sex hormone concentrations, such as pregnancy, may prove 
      critical.
CI  - Copyright (c) 2023 Soedirdjo, Rodriguez, Chung, Casey and Dhaher.
FAU - Soedirdjo, Subaryani D H
AU  - Soedirdjo SDH
AD  - Department of Physical Medicine and Rehabilitation, UT Southwestern Medical 
      Center, Dallas, TX, United States.
FAU - Rodriguez, Luis A 2nd
AU  - Rodriguez LA 2nd
AD  - Department of Physical Medicine and Rehabilitation, UT Southwestern Medical 
      Center, Dallas, TX, United States.
AD  - Department of Bioengineering, University of Texas at Dallas, Richardson, TX, 
      United States.
AD  - Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX, 
      United States.
FAU - Chung, Yu-Chen
AU  - Chung YC
AD  - Department of Physical Medicine and Rehabilitation, UT Southwestern Medical 
      Center, Dallas, TX, United States.
FAU - Casey, Ellen
AU  - Casey E
AD  - Department of Physiatry, Hospital for Special Surgery, New York, NY, United 
      States.
FAU - Dhaher, Yasin Y
AU  - Dhaher YY
AD  - Department of Physical Medicine and Rehabilitation, UT Southwestern Medical 
      Center, Dallas, TX, United States.
AD  - Department of Bioengineering, University of Texas at Dallas, Richardson, TX, 
      United States.
AD  - Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX, 
      United States.
LA  - eng
PT  - Journal Article
DEP - 20230307
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC10029997
OTO - NOTNLM
OT  - half relaxation time
OT  - menstrual cycle
OT  - muscle activation deactivation dynamics
OT  - sex hormone
OT  - time to peak torque
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/25 06:00
MHDA- 2023/03/25 06:01
PMCR- 2023/03/07
CRDT- 2023/03/24 02:21
PHST- 2022/11/21 00:00 [received]
PHST- 2023/02/22 00:00 [accepted]
PHST- 2023/03/24 02:21 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/25 06:01 [medline]
PHST- 2023/03/07 00:00 [pmc-release]
AID - 1104578 [pii]
AID - 10.3389/fphys.2023.1104578 [doi]
PST - epublish
SO  - Front Physiol. 2023 Mar 7;14:1104578. doi: 10.3389/fphys.2023.1104578. 
      eCollection 2023.