PMID- 36961144
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230916
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 12
DP  - 2023 Mar 24
TI  - Evaluation of prognostic inflammatory and systemic inflammatory response indices 
      in auxiliary diagnosis of bacteria-negative pulmonary tuberculosis: A diagnostic 
      accuracy study.
PG  - e33372
LID - 10.1097/MD.0000000000033372 [doi]
LID - e33372
AB  - Although molecular biology has made great progress in recent years, the detection 
      rate of mycobacterium tuberculosis (MTB) is still not ideal. This study aimed to 
      evaluate the role of prognostic inflammatory index (PII) and systemic 
      inflammatory response index (SIRI) in the auxiliary diagnosis of 
      bacteria-negative pulmonary tuberculosis (TB). Sixty patients diagnosed with 
      bacteria-negative pulmonary TB at the Affiliated Hospital of Qinghai University 
      between October 2019 and September 2022 were randomly selected as the case group, 
      and seventy patients with nontuberculous pulmonary infection in the same 
      department of the same hospital during the same period were randomly selected as 
      the control group. Baseline data and values of erythrocyte sedimentation rate 
      (ESR), lymphocyte count (LY), neutrophil count (NE), monocyte count (MO), albumin 
      (ALB), prealbumin (PA), C-reactive protein (CRP), fibrinogen (FIB), 
      neutrophil-to-lymphocyte ratio (NLR), PII, and SIRI were compared between the 2 
      groups. Receiver operating characteristic (ROC) curves were used to evaluate the 
      diagnostic efficacy of PII and SIRI in the diagnosis of bacteria-negative 
      pulmonary TB. No significant differences were found between the 2 groups in terms 
      of sex and age (P > .05); however significant differences were observed in 
      relation to body mass index (BMI), ESR, LY, NE, MO, ALB, PA, CRP, FIB, NLR, PII, 
      and SIRI (P < .05). ROC curve analysis showed that area under curve (AUC) value 
      0.84 [95% CI (0.77, 0.90)] and specificity 82.86% [95% CI (72.0, 90.8)] of 
      PII were the highest, while the sensitivity 86.67 [95% CI (75.4, 94.1)] of NLR 
      + PII was the highest. Pairwise comparison of the 7 indicators of ROC curve was 
      performed, and only the diagnostic efficiency of NLR and NLR + PII was 
      statistically significant (Z = 2.36, P = .02 < .05). NLR, PII, SIRI, pairwise 
      combinations, and NLR + PII + SIRI showed auxiliary diagnostic values for 
      bacteria-negative pulmonary TB, among which PII had the highest diagnostic value 
      and specificity, while NLR + PII had the highest sensitivity.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Chai, Bofeng
AU  - Chai B
AD  - Qinghai University, Xining, Qinghai, China.
FAU - Wu, Dan
AU  - Wu D
AD  - Qinghai University Affiliated Hospital, Xining, Qinghai, China.
FAU - Fu, Na
AU  - Fu N
AD  - Qinghai University, Xining, Qinghai, China.
FAU - Huang, Ping
AU  - Huang P
AD  - Lanzhou University, Lanzhou, China.
FAU - Shen, Youlu
AU  - Shen Y
AUID- ORCID: 0000-0002-7787-0368
AD  - Qinghai University Affiliated Hospital, Xining, Qinghai, China.
FAU - Li, Yuhong
AU  - Li Y
AD  - Qinghai University Affiliated Hospital, Xining, Qinghai, China.
FAU - Wang, Yinghong
AU  - Wang Y
AD  - Minle County People's Hospital, Gansu, Zhangye, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Albumins)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - *Mycobacterium tuberculosis
MH  - Retrospective Studies
MH  - C-Reactive Protein/analysis
MH  - Lymphocytes/metabolism
MH  - *Tuberculosis, Pulmonary/diagnosis
MH  - Neutrophils/metabolism
MH  - Albumins/analysis
MH  - Fibrinogen/analysis
MH  - Systemic Inflammatory Response Syndrome
PMC - PMC10036059
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2023/03/25 06:00
MHDA- 2023/03/28 19:05
PMCR- 2023/03/24
CRDT- 2023/03/24 08:53
PHST- 2023/03/28 19:05 [medline]
PHST- 2023/03/24 08:53 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/24 00:00 [pmc-release]
AID - 00005792-202303240-00015 [pii]
AID - 10.1097/MD.0000000000033372 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Mar 24;102(12):e33372. doi: 
      10.1097/MD.0000000000033372.