PMID- 36961333
OWN - NLM
STAT- MEDLINE
DCOM- 20230511
LR  - 20230624
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 63
IP  - 5
DP  - 2023 May
TI  - Modeling unrelated blood stem cell donor recruitment using simulated registrant 
      cohorts: Assessment of human leukocyte antigen matching across ethnicity groups.
PG  - 1060-1066
LID - 10.1111/trf.17310 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-matched unrelated donors are not 
      available for some patients considered for allogeneic hematopoietic cell 
      transplantation, particularly among certain ethnic groups. Simulated recruitment 
      modeling can inform efforts to find new matches for more patients. METHODS: 
      Simulated recruits were generated by assigning a pair of donor HLA haplotypes 
      from historical data files and matched against HLA data of patient searches in 
      the Canadian Blood Services Stem Cell Registry. Recruitment cohorts reflected the 
      proportion of five specific ethnic groups in the 2016 Canadian census data. 
      RESULTS: Novel 8/8 HLA matches between simulated recruits and patients increased 
      linearly with larger recruitment cohorts. The proportion of novel 8/8 HLA matches 
      from Caucasian, Hispanic, and Native American/First Nations recruits was equal to 
      or greater than their relative proportion in the recruited cohort (match to: 
      recruit ratio (MRR) >/= 1). In contrast, African American and Asian & Pacific 
      Islander recruits represented a smaller proportion of novel matches relative to 
      their percentage of the recruited cohort (MRR <1). The proportion of novel 7/8 
      HLA-matches from each ethnic group was approximately the same as their proportion 
      in the recruited cohort (MRR ~ 1) and high rates of 7/8 HLA-matching already 
      exist within the Canadian Blood Services registry for all ethnic groups. 
      CONCLUSION: Continued large recruitment cohorts are needed to add new 8/8 HLA 
      matches to registry inventories. Likelihoods of novel HLA matches varied across 
      ethnic groups, reflecting varied HLA haplotype frequencies across groups. 
      Simulated cohort modeling can inform recruitment strategies that will generate 
      new donor options for patients.
CI  - (c) 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of 
      AABB.
FAU - Blake, John T
AU  - Blake JT
AUID- ORCID: 0000-0003-0617-8996
AD  - Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
AD  - Department of Industrial Engineering, Faculty of Engineering, Dalhousie 
      University, Halifax, Nova Scotia, Canada.
FAU - Parmar, Gaganvir
AU  - Parmar G
AD  - Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
FAU - Ganz, Kathy
AU  - Ganz K
AD  - Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
FAU - Seftel, Matthew D
AU  - Seftel MD
AD  - Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
AD  - Department of Medicine, Faculty of Medicine, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Allan, David S
AU  - Allan DS
AUID- ORCID: 0000-0003-3261-8289
AD  - Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
AD  - Department of Medicine, and Biochemistry, Microbiology & Immunology, Faculty of 
      Medicine, University of Ottawa, Ottawa, Ontario, Canada.
AD  - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, 
      Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230324
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - *Unrelated Donors
MH  - Ethnicity
MH  - Histocompatibility Testing
MH  - Canada
MH  - *Hematopoietic Stem Cell Transplantation
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class I
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II
MH  - Stem Cells
MH  - Registries
OTO - NOTNLM
OT  - HLA-matching
OT  - allogeneic
OT  - hematopoietic cell transplant
OT  - simulated recruitment
OT  - stem cell registry
EDAT- 2023/03/25 06:00
MHDA- 2023/05/11 06:42
CRDT- 2023/03/24 10:12
PHST- 2023/02/10 00:00 [revised]
PHST- 2022/12/12 00:00 [received]
PHST- 2023/02/12 00:00 [accepted]
PHST- 2023/05/11 06:42 [medline]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/24 10:12 [entrez]
AID - 10.1111/trf.17310 [doi]
PST - ppublish
SO  - Transfusion. 2023 May;63(5):1060-1066. doi: 10.1111/trf.17310. Epub 2023 Mar 24.