PMID- 36962976
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230327
IS  - 2767-3375 (Electronic)
IS  - 2767-3375 (Linking)
VI  - 3
IP  - 2
DP  - 2023
TI  - Acceptability, feasibility, and accuracy of blood-based HIV self-testing: A 
      cross-sectional study in Ho Chi Minh City, Vietnam.
PG  - e0001438
LID - 10.1371/journal.pgph.0001438 [doi]
LID - e0001438
AB  - HIV self-testing (HIVST) is an effective approach to increase testing uptake. 
      While oral fluid-based HIVST has been rapidly scaled, use of blood-based HIVST 
      remains limited. We evaluated the acceptability, feasibility, and accuracy of 
      blood-based HIVST among lay users in Ho Chi Minh City (HCMC), Vietnam. We 
      conducted a cross-sectional study among HIV testing clients at the HCMC Pasteur 
      Institute from March 2019 to October 2020. Participants received one HIVST kit 
      and performed the test in front of an observer. The observer used 
      product-specific questionnaires to collect information on the HIVST process, test 
      results, experiences. The participants' interpretations of HIVST results were 
      compared to health staff's interpretations and gold standard laboratory EIA 
      reference tests. Of 2,399 participants who accepted HIVST, 64.7% were men, 62.1% 
      aged 25-49 years, 53.5% had a higher education level, 41.4% were employed, and 
      35.6% were first-time testers. The vast majority (94.4%) desired to use the test 
      in the future, and 93.9% reported willingness to recommend the test. The majority 
      (90.8%) of participants successfully completed the self-test. One factor 
      associated with successful completion was higher education level (aOR = 1.85; 95% 
      CI: 1.32-2.61); while participants self-testing with SURE CHECK (aOR = 0.21; 95% 
      CI: 0.12-0.37), INSTI (aOR = 0.23; 95% CI: 0.13-0.39), and BioSURE (aOR = 0.29; 
      95% CI: 0.17-0.51) or being unemployed, retired, or doing housework (aOR = 0.45; 
      95% CI: 0.25-0.82) were less likely to perform the test successfully. Agreement 
      of positive and negative HIVST results as interpreted by participants and health 
      staff was high (98.1% and 99.9%, respectively). Sensitivity and specificity of 
      the evaluated HIVST were 96.43% (95% CI: 93.62-99.23) and 99.9% (95% CI: 
      99.75-100), respectively. Our findings confirm that blood-based HIVST is highly 
      acceptable, feasible, and accurate. This evidence informs scale-up of HIVST to 
      increase uptake of essential HIV prevention and treatment services.
CI  - Copyright: (c) 2023 Ngoc et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Ngoc, Bao Vu
AU  - Ngoc BV
AUID- ORCID: 0000-0002-5529-5411
AD  - PATH, Hanoi, Vietnam.
FAU - Majam, Mohammed
AU  - Majam M
AUID- ORCID: 0000-0003-0302-5353
AD  - Ezintsha, Wits Health Consortium, University of the Witwatersrand, Johannesburg, 
      South Africa.
FAU - Green, Kimberly
AU  - Green K
AD  - PATH, Hanoi, Vietnam.
FAU - Tran, Ton
AU  - Tran T
AUID- ORCID: 0000-0003-4473-878X
AD  - Pasteur Institute, Ho Chi Minh City, Vietnam.
FAU - Hung, Minh Tran
AU  - Hung MT
AD  - Center for Creative Initiatives in Health and Population, Hanoi, Vietnam.
FAU - Que, Anh Luong
AU  - Que AL
AD  - Pasteur Institute, Ho Chi Minh City, Vietnam.
FAU - Ngoc, Diep Bui
AU  - Ngoc DB
AD  - Center for Creative Initiatives in Health and Population, Hanoi, Vietnam.
FAU - Le Duy, Chuong Hoang
AU  - Le Duy CH
AD  - Pasteur Institute, Ho Chi Minh City, Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20230201
PL  - United States
TA  - PLOS Glob Public Health
JT  - PLOS global public health
JID - 9918283779606676
PMC - PMC10022389
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/25 06:00
MHDA- 2023/03/25 06:01
PMCR- 2023/02/01
CRDT- 2023/03/24 18:26
PHST- 2022/09/15 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/03/24 18:26 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/25 06:01 [medline]
PHST- 2023/02/01 00:00 [pmc-release]
AID - PGPH-D-22-01517 [pii]
AID - 10.1371/journal.pgph.0001438 [doi]
PST - epublish
SO  - PLOS Glob Public Health. 2023 Feb 1;3(2):e0001438. doi: 
      10.1371/journal.pgph.0001438. eCollection 2023.