PMID- 36963011
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230327
IS  - 2767-3375 (Electronic)
IS  - 2767-3375 (Linking)
VI  - 3
IP  - 2
DP  - 2023
TI  - Increased adverse events following third dose of BNT162b2/Pfizer vaccine in those 
      with previous COVID-19, but not with concurrent influenza vaccine.
PG  - e0001053
LID - 10.1371/journal.pgph.0001053 [doi]
LID - e0001053
AB  - Prior studies suggest that adverse events (AEs) following doses one and two of 
      BNT162b2/Pfizer vaccine are worse in those with a prior history of COVID-19. To 
      establish whether this outcome applies to a third/booster dose, we conducted a 
      survey with 534 healthcare workers (HCW) in Northeast England, who reported AEs 
      following all three doses of BNT162b2/Pfizer vaccine. We also explored AEs 
      associated with concurrent seasonal influenza immunisation, in a subset of 492 
      HCWs. For all doses of BNT162b2/Pfizer vaccine there was a cluster of systemic 
      AEs that were consistently worse in HCWs with a prior history of COVID-19. AEs 
      were no worse in HCWs who received their third/booster dose within 7 days of the 
      influenza jab, rather than further apart. Gender and the presence of ongoing 
      COVID-19 symptoms (OCS) had no effect on AEs associated with COVID-19 or 
      influenza vaccination, though younger HCWs experienced more AEs overall. Our 
      findings have implications for vaccine hesitancy and immunisation protocols.
CI  - Copyright: (c) 2023 Raw et al. This is an open access article distributed under the 
      terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Raw, Rachael K
AU  - Raw RK
AUID- ORCID: 0000-0001-7593-3436
AD  - School of Medicine and Health, Newcastle University, Newcastle upon Tyne, United 
      Kingdom.
FAU - Rees, Jon
AU  - Rees J
AUID- ORCID: 0000-0002-3295-244X
AD  - The School of Psychology, University of Sunderland, Sunderland, United Kingdom.
FAU - Chadwick, David R
AU  - Chadwick DR
AD  - Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, 
      United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20230217
PL  - United States
TA  - PLOS Glob Public Health
JT  - PLOS global public health
JID - 9918283779606676
PMC - PMC10021629
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/25 06:00
MHDA- 2023/03/25 06:01
PMCR- 2023/02/17
CRDT- 2023/03/24 18:27
PHST- 2022/08/17 00:00 [received]
PHST- 2023/01/23 00:00 [accepted]
PHST- 2023/03/24 18:27 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/25 06:01 [medline]
PHST- 2023/02/17 00:00 [pmc-release]
AID - PGPH-D-22-01340 [pii]
AID - 10.1371/journal.pgph.0001053 [doi]
PST - epublish
SO  - PLOS Glob Public Health. 2023 Feb 17;3(2):e0001053. doi: 
      10.1371/journal.pgph.0001053. eCollection 2023.