PMID- 36963428
OWN - NLM
STAT- MEDLINE
DCOM- 20230504
LR  - 20230504
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 55
IP  - 5
DP  - 2023 May
TI  - Detailed Review on Gestational Diabetes Mellitus with Emphasis on 
      Pathophysiology, Epidemiology, Related Risk Factors, and its Subsequent 
      Conversion to Type 2 Diabetes Mellitus.
PG  - 295-303
LID - 10.1055/a-2061-9441 [doi]
AB  - Any degree of glucose intolerance during the pregnancy of a women is termed as 
      Gestational Diabetes Mellitus (GDM). It may further develop into Type 2 Diabetes 
      Mellitus (T2DM) later in life. GDM affects both mother and infant in multiple 
      ways and there are various factors that predispose the development of GDM.The 
      primary objective of this review is to describe the various aspects related to 
      GDM and the subsequent risk of developing T2DM later in life.We reviewed freely 
      accessible, full-text articles, available in PubMed, Google Scholar, and MEDLINE 
      in the English language, till August 2022 pertaining to GDM.The pathophysiology 
      of underlying glucose intolerance has been discussed, including the various 
      factors like beta-Cell dysfunction, chronic insulin resistance, adiponectin, insulin 
      resistance. GDM affects pregnancies world-wide, but it is higher in the 
      South-east Asia, northern America and Caribbean, south and central America 
      regions. Along with ethnicity, various modifiable and non-modifiable risk factors 
      also play a major role in development of disease. Although no standard diagnostic 
      criteria is accepted world-wide for screening of GDM, but the one-step and 
      two-step approach has made quite a difference. The risk of developing T2DM after 
      GDM is well documented, and it increases with age. GDM leads to an onset of 
      diabetes in the family at a young age, it leads to poor consequences on the 
      health of both the mother and infant. Standard diagnostic criteria, proper 
      education and counselling of the mother is required to tackle the condition.
CI  - Thieme. All rights reserved.
FAU - Gajera, Dhruvil
AU  - Gajera D
AUID- ORCID: 0000-0002-4545-5274
AD  - Department of Pharmacy Practice, Parul Institute of Pharmacy, Vadodara, India.
FAU - Trivedi, Vishva
AU  - Trivedi V
AUID- ORCID: 0000-0002-5452-3195
AD  - Department of Pharmacy Practice, Parul Institute of Pharmacy, Vadodara, India.
FAU - Thaker, Priyanshu
AU  - Thaker P
AD  - Department of Pharmacy Practice, Parul Institute of Pharmacy, Vadodara, India.
FAU - Rathod, Mrudang
AU  - Rathod M
AD  - Department of Pharmacy Practice, Parul Institute of Pharmacy, Vadodara, India.
FAU - Dharamsi, Abhay
AU  - Dharamsi A
AD  - Department of Pharmacy Practice, Parul Institute of Pharmacy, Vadodara, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230324
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Diabetes, Gestational/epidemiology/etiology/diagnosis
MH  - *Diabetes Mellitus, Type 2/etiology/complications
MH  - *Insulin Resistance
MH  - *Glucose Intolerance/epidemiology
MH  - Risk Factors
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/03/25 06:00
MHDA- 2023/05/04 12:42
CRDT- 2023/03/24 20:12
PHST- 2023/05/04 12:42 [medline]
PHST- 2023/03/25 06:00 [pubmed]
PHST- 2023/03/24 20:12 [entrez]
AID - 10.1055/a-2061-9441 [doi]
PST - ppublish
SO  - Horm Metab Res. 2023 May;55(5):295-303. doi: 10.1055/a-2061-9441. Epub 2023 Mar 
      24.