PMID- 36963852
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230422
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 54
DP  - 2023 Apr
TI  - Premeal almond load decreases postprandial glycaemia, adiposity and reversed 
      prediabetes to normoglycemia: A randomized controlled trial.
PG  - 12-22
LID - S2405-4577(22)01438-3 [pii]
LID - 10.1016/j.clnesp.2022.12.028 [doi]
AB  - BACKGROUND: Asian Indians show rapid conversion from prediabetes to type 2 
      diabetes (T2D). Novel dietary strategies are needed to arrest this progression, 
      by targeting postprandial hyperglycaemia (PPHG). DESIGN: We conducted a 
      free-living randomized controlled open-label parallel arm study to evaluate the 
      effect of a premeal load of almonds (20 g) 30 min before major meals on 
      anthropometric, glycaemic, and metabolic parameters over 3 months. Sixty-six 
      participants with prediabetes in the age range of 18-60 yrs were recruited. The 
      study was registered at clinicaltrials.gov (registration no. NCT04769726). 
      RESULTS: Thirty participants in each arm completed the study. As per 
      'intention-to-treat' analysis, overall additional mean reductions were 
      statistically significant for body weight, BMI, waist circumference (WC), 
      subscapular and suprailiac skinfolds, and improved handgrip strength (Kg) 
      (p < 0.001 for all) in the treatment arm vs. the control arm (after multiple 
      adjustments). In the blood parameters, the additional mean reduction in the 
      treatment arm vs. control arm was statistically significant for fasting and 
      post-75 g oral glucose-load blood glucose, postprandial insulin, HOMA-IR, HbA1c, 
      proinsulin, total cholesterol, and very low-density lipoprotein cholesterol 
      (p < 0.001 for all). Most importantly, we observed a reversal to normoglycemic 
      state (fasting blood glucose and 2 h post-OGTT glucose levels) in 23.3% (7 out of 
      30) of participants in the treatment arm which is comparable to that seen with 
      Acarbose treatment (25%). CONCLUSION: Incorporation of 20 g of almonds, 30 min 
      before each major meal leads to significant improvement in body weight, WC, 
      glycemia (particularly PPHG), and insulin resistance and shows potential for 
      reversal of prediabetes to normal glucose regulation over 3 months.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Gulati, Seema
AU  - Gulati S
AD  - Diabetes Foundation (India), New Delhi, India; National Diabetes, Obesity and 
      Cholesterol Foundation (N-DOC), New Delhi, India; Center of Nutrition & Metabolic 
      Research (C-NET), New Delhi, India.
FAU - Misra, Anoop
AU  - Misra A
AD  - Diabetes Foundation (India), New Delhi, India; National Diabetes, Obesity and 
      Cholesterol Foundation (N-DOC), New Delhi, India; Center of Nutrition & Metabolic 
      Research (C-NET), New Delhi, India; Fortis C-DOC Centre for Excellence for 
      Diabetes, Metabolic Disease, and Endocrinology, New Delhi, India. Electronic 
      address: anoopmisra@gmail.com.
FAU - Tiwari, Rajneesh
AU  - Tiwari R
AD  - National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India.
FAU - Sharma, Meenu
AU  - Sharma M
AD  - National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India.
FAU - Pandey, Ravindra M
AU  - Pandey RM
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Upadhyay, Ashish Datt
AU  - Upadhyay AD
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Chandra Sati, Hem
AU  - Chandra Sati H
AD  - All India Institute of Medical Sciences, New Delhi, India.
LA  - eng
SI  - ClinicalTrials.gov/NCT04769726
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20221229
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Blood Glucose)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Middle Aged
MH  - *Prediabetic State
MH  - Blood Glucose/metabolism
MH  - *Prunus dulcis/metabolism
MH  - Adiposity
MH  - *Diabetes Mellitus, Type 2
MH  - Hand Strength
MH  - Obesity
MH  - Body Weight
MH  - *Hyperglycemia
MH  - Cholesterol
OTO - NOTNLM
OT  - Almonds
OT  - Asian Indians
OT  - Postprandial glucose regulators
OT  - Postprandial hyperglycaemia
OT  - Prediabetes
EDAT- 2023/03/25 06:00
MHDA- 2023/03/28 17:16
CRDT- 2023/03/24 21:55
PHST- 2022/09/27 00:00 [received]
PHST- 2022/12/17 00:00 [revised]
PHST- 2022/12/23 00:00 [accepted]
PHST- 2023/03/28 17:16 [medline]
PHST- 2023/03/24 21:55 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
AID - S2405-4577(22)01438-3 [pii]
AID - 10.1016/j.clnesp.2022.12.028 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2023 Apr;54:12-22. doi: 10.1016/j.clnesp.2022.12.028. Epub 2022 
      Dec 29.