PMID- 36963867
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230422
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 54
DP  - 2023 Apr
TI  - N-acetylecysteine, a powerful agent in the reinforcement of anti-oxidant profile: 
      A systematic review and dose-response meta-analysis of controlled clinical 
      trials.
PG  - 227-238
LID - S2405-4577(23)00023-2 [pii]
LID - 10.1016/j.clnesp.2023.01.021 [doi]
AB  - BACKGROUND AND AIM: Several studies have been conducted to evaluate the effect of 
      N-acetylecysteine (NAC) supplementation on antioxidant status, while no 
      dose-response meta-analysis summarized the efficacy of NAC supplementation. 
      METHODS: The systematic search of literatures was conducted on Scopus, PubMed, 
      Embase, Web of Science electronic databases. Controlled clinical trials 
      investigating the effects of NAC on antioxidant biomarkers were included in the 
      current meta-analysis. Random-effect model was used to perform meta-analysis. 
      Heterogeneity was examined using I(2) index. Subgroup analysis was carried out to 
      find the possible sources of heterogeneity. Dose-response analysis was performed 
      to find the non-linear relationships between effect size and independent 
      variables. RESULTS: Overall, 26 eligible studies were included in the review. NAC 
      supplementation significantly increased TAC (SMD = 0.77 mumol/L; 95% CI: 0.38, 
      1.16; p < 0.001), GSH (SMD = 0.80 nmol/ml; 95% CI:0.25, 1.34; p = 0.004) and CAT 
      (SMD = -0.57 IU/L; 95% CI:-1.13, -0.02; p = 0.042) levels. However, no 
      significant improving effect was observed in terms of GR (SMD = 0.25 IU/g; 95% 
      CI:-0.14, 0.63; p = 0.210), SOD (SMD = 0.14 U/ml; 95% CI:-0.20, 0.49; p = 0.414) 
      and GPx (SMD = 0.19 IU/g; 95% CI:-0.48, 0.86; p = 0.576) levels. Furthermore, 
      dose-response analysis show that NAC supplementation in participants with mean 
      age up to 30 years had more robust effect on increasing GSH levels. CONCLUSION: 
      We found a significant effect of NAC supplementation on TAC, GSH, CAT in adults. 
      Overall, NAC could be considered as a potent agent in enhancing antioxidant 
      capacity.
CI  - Copyright (c) 2023 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Mahmoudinezhad, Mahsa
AU  - Mahmoudinezhad M
AD  - Nutrition Research Center, Department of Community Nutrition, Student Research 
      Committee, School of Nutrition and Food Science, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Abbaszadeh, Fatemeh
AU  - Abbaszadeh F
AD  - Nutrition Research Center, Department of Nutrition and Diet Therapy, Student 
      Research Committee, School of Nutrition and Food Science, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Zarezadeh, Meysam
AU  - Zarezadeh M
AD  - Nutrition Research Center, Department of Clinical Nutrition, Student Research 
      Committee, School of Nutrition and Food Science, Tabriz University of Medical 
      Sciences, Tabriz, Iran. Electronic address: meysam.za93@gmail.com.
FAU - Bahreini, Nazgol
AU  - Bahreini N
AD  - Nutrition Research Center, Department of Nutrition and Diet Therapy, Student 
      Research Committee, School of Nutrition and Food Science, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Jamilian, Parsa
AU  - Jamilian P
AD  - Keele Medical School, Keele University, Staffordshire, UK.
FAU - Jamilian, Parmida
AU  - Jamilian P
AD  - School of Pharmacy and Bio Engineering, Keele University, Staffordshire, UK.
FAU - Ostadrahimi, Alireza
AU  - Ostadrahimi A
AD  - Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition 
      and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. 
      Electronic address: ostadrahimi@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20230124
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Antioxidants/pharmacology
MH  - *Dietary Supplements
MH  - Oxidative Stress
MH  - Biomarkers/metabolism
OTO - NOTNLM
OT  - Anti-oxidant
OT  - Meta-analysis
OT  - N-acetylecysteine
OT  - Oxidative stress
OT  - Systematic review
COIS- Declaration of competing interest None.
EDAT- 2023/03/25 06:00
MHDA- 2023/03/28 17:16
CRDT- 2023/03/24 21:55
PHST- 2022/07/12 00:00 [received]
PHST- 2022/12/18 00:00 [revised]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/03/28 17:16 [medline]
PHST- 2023/03/24 21:55 [entrez]
PHST- 2023/03/25 06:00 [pubmed]
AID - S2405-4577(23)00023-2 [pii]
AID - 10.1016/j.clnesp.2023.01.021 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2023 Apr;54:227-238. doi: 10.1016/j.clnesp.2023.01.021. Epub 
      2023 Jan 24.