PMID- 36966773
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230916
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 35
IP  - 5
DP  - 2023 May 1
TI  - Accuracy and concordance of two-dimensional shear-wave elastography using 
      transient elastography as the reference in chronic viral hepatitis and HIV 
      infection in Rio de Janeiro, Brazil.
PG  - 583-590
LID - 10.1097/MEG.0000000000002537 [doi]
AB  - OBJECTIVES: Evaluate the accuracy and agreement of two-dimensional shear-wave 
      elastography (2D-SWE) LOGIQ-S8 with transient elastography in patients from Rio 
      de Janeiro, Brazil. METHOD: This retrospective study compared liver stiffness 
      measurements (LSMs) using transient elastography (M and XL probes) and 2D-SWE 
      GE-LOGIQ-S8 performed by a single experienced operator on the same day in 348 
      consecutive individuals with viral hepatitis or HIV infection. Suggestive and 
      highly suggestive compensated-advanced chronic liver disease (c-ACLD) were 
      defined by transient elastography-LSM >/=10 kPa and >/=15 kPa, respectively. 
      Agreement between techniques and accuracy of 2D-SWE using transient 
      elastography-M probe as the reference was assessed. Optimal cut-offs for 2D-SWE 
      were identified using the maximal Youden index. RESULTS: Three hundred five 
      patients [61.3% male, median age = 51 [interquartile range (IQR), 42-62] years, 
      24% with hepatitis C virus (HCV) +/- HIV; 17% with hepatitis B virus (HBV) +/- HIV; 
      31% were HIV mono-infected and 28% had HCV +/- HIV post-sustained virological 
      response] were included. The overall correlation (Spearman's rho ) was moderate 
      between 2D-SWE and transient elastography-M ( rho  = 0.639) and weak between 2D-SWE 
      and transient elastography-XL ( rho  = 0.566). Agreements were strong ( rho  > 0.800) 
      in people with HCV or HBV mono-infection, and poor in HIV mono-infected ( rho 
       > 0.400). Accuracy of 2D-SWE for transient elastography-M >/= 10 kPa [area under 
      the receiver operating characteristic (AUROC) = 0.91 (95% confidence interval 
      [CI], 0.86-0.96); optimal cut-off = 6.4 kPa, sensitivity = 84% (95% CI, 72-92), 
      specificity = 89% (95% CI, 84-92)] and for transient elastography-M >/= 15 kPa 
      [AUROC = 0.93 (95% CI, 0.88-0.98); optimal cut-off = 7.1 kPa; sensitivity = 91% 
      (95% CI, 75-98), specificity = 89% (95% CI, 85-93)] were excellent. CONCLUSION: 
      2D-SWE LOGIQ-S8 system had a good agreement with transient elastography and an 
      excellent accuracy to identify individuals at high risk for c-ACLD.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Coelho, Mariana
AU  - Coelho M
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Fernandes, Flavia
AU  - Fernandes F
AD  - Hepatology Department, Bonsucesso Federal Hospital.
FAU - Cardoso, Sandra W
AU  - Cardoso SW
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Piedade, Juliana
AU  - Piedade J
AD  - Hepatology Department, Bonsucesso Federal Hospital.
AD  - Estacio de Sa University, School of Medicine, Rio de Janeiro, Brazil.
FAU - Torres da Silva, Marcos Vinicius
AU  - Torres da Silva MV
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Santos, Ricardo
AU  - Santos R
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Veloso, Valdilea G
AU  - Veloso VG
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Grinsztejn, Beatriz
AU  - Grinsztejn B
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
FAU - Pereira, Gustavo Henrique
AU  - Pereira GH
AD  - Hepatology Department, Bonsucesso Federal Hospital.
AD  - Estacio de Sa University, School of Medicine, Rio de Janeiro, Brazil.
FAU - Perazzo, Hugo
AU  - Perazzo H
AD  - Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS), Oswaldo Cruz 
      Foundation (FIOCRUZ), National Institute of Infectious Diseases Evandro Chagas 
      (INI).
LA  - eng
PT  - Journal Article
DEP - 20230318
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Female
MH  - Liver Cirrhosis/diagnostic imaging
MH  - Retrospective Studies
MH  - *Elasticity Imaging Techniques/methods
MH  - Brazil/epidemiology
MH  - *HIV Infections/complications
MH  - *Liver Diseases
MH  - Hepatitis, Chronic
MH  - *Hepatitis C
MH  - *Hepatitis B
MH  - Hepatitis B virus
MH  - Liver/diagnostic imaging
EDAT- 2023/03/27 06:00
MHDA- 2023/05/01 06:42
CRDT- 2023/03/26 19:53
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/03/27 06:00 [pubmed]
PHST- 2023/03/26 19:53 [entrez]
AID - 00042737-202305000-00010 [pii]
AID - 10.1097/MEG.0000000000002537 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2023 May 1;35(5):583-590. doi: 
      10.1097/MEG.0000000000002537. Epub 2023 Mar 18.