PMID- 36966806
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230929
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 34
IP  - 6
DP  - 2023 Apr 5
TI  - Comparison of motor function recovery and brain changes in intracerebral 
      hemorrhagic and ischemic rats with similar brain damage.
PG  - 332-337
LID - 10.1097/WNR.0000000000001898 [doi]
AB  - In this study, we compared the mechanisms of brain recovery in intracerebral 
      hemorrhage and ischemia, focusing on synapses, glial cells, and dopamine 
      expression, which are considered fundamental for neural recovery after stroke. 
      Male Wistar rats were divided into intracerebral hemorrhage, ischemia, and sham 
      surgery (SHAM) groups. The intracerebral hemorrhage group was injected with a 
      collagenase solution, the ischemia group was injected with an endothelin-1 
      solution, and the SHAM group was injected with physiological saline. The motor 
      function of these rats was evaluated using a rotarod test on days 7, 14, 21, and 
      28 post-surgery. On postoperative day 29, lesion volume was analyzed using Nissl 
      staining. In addition, the protein expression levels of NeuN, GFAP, tyrosine 
      hydroxylase, and PSD95 were analyzed in the striatum and motor cortex. There was 
      no significant difference between the ischemia and intracerebral hemorrhage 
      groups in terms of lesion volume in the striatum; however, the motor recovery of 
      the intracerebral hemorrhage group occurred more rapidly than that of the 
      ischemia group, and the intracerebral hemorrhage group exhibited higher GFAP 
      protein expression in the motor cortex. The rapid motor recovery in intracerebral 
      hemorrhage rats relative to that in ischemia rats may be associated with changes 
      in astrocytes in brain regions remote from the injury site.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Tamakoshi, Keigo
AU  - Tamakoshi K
AD  - Department of Physical Therapy, Niigata University of Health and Welfare.
AD  - Institute for Human Movement and Medical Sciences.
FAU - Meguro, Kota
AU  - Meguro K
AD  - Department of Rehabilitation, Kaetsu Hospital.
FAU - Takahashi, Yuri
AU  - Takahashi Y
AD  - Department of Rehabilitation, Aizawa Hospital.
FAU - Oshimi, Ryu
AU  - Oshimi R
AD  - Department of Rehabilitation, Saigata Medical Center, National Hospital 
      Organization.
FAU - Iwasaki, Natsuka
AU  - Iwasaki N
AD  - Department of Rehabilitation, Azuma Neurosurgical Hospital, Niigata, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230314
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - Rats, Wistar
MH  - Recovery of Function/physiology
MH  - *Cerebral Hemorrhage
MH  - Brain
MH  - Ischemia
MH  - *Brain Injuries
MH  - Disease Models, Animal
EDAT- 2023/03/27 06:00
MHDA- 2023/04/05 06:42
CRDT- 2023/03/26 20:02
PHST- 2023/04/05 06:42 [medline]
PHST- 2023/03/27 06:00 [pubmed]
PHST- 2023/03/26 20:02 [entrez]
AID - 00001756-202304010-00007 [pii]
AID - 10.1097/WNR.0000000000001898 [doi]
PST - ppublish
SO  - Neuroreport. 2023 Apr 5;34(6):332-337. doi: 10.1097/WNR.0000000000001898. Epub 
      2023 Mar 14.