PMID- 36967750
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230328
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - A bi-directional Mendelian randomization study of sarcopenia-related traits and 
      type 2 diabetes mellitus.
PG  - 1109800
LID - 10.3389/fendo.2023.1109800 [doi]
LID - 1109800
AB  - BACKGROUND: Previous studies have reported an association between sarcopenia and 
      type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. 
      A more robust research approach is urgently required to investigate the causal 
      relationship between sarcopenia and T2DM. METHODS: The bi-directional two-sample 
      MR study was carried out in two stages: Sarcopenia-related traits were 
      investigated as exposure while T2DM was investigated as an outcome in the first 
      step, whereas the second step was reversed. The GWAS summary data for hand-grip 
      strength (n = 256,523), appendicular lean mass (ALM, n = 450,243), and walking 
      pace (n = 459,915) were obtained from the UK Biobank. T2DM data were obtained 
      from one of the biggest case-control studies on diabetes (DIAGRAM; n = 180,834 
      cases and 492,191 controls), which was published in 2022. The inverse-variance 
      weighted (IVW) approach was used to obtain MR estimates, and various sensitivity 
      analysis was also performed. RESULTS: Low hand-grip strength had a potential 
      causal relationship with an increased incidence of T2DM (OR = 1.109; 95% CI, 
      1.008-1.222; p = 0.0350). T2DM risk was reduced by increasing ALM and walking 
      pace: A 1 kg/m(2) increase in ALM decreased the risk of T2DM by 10.2% (OR = 
      0.898; 95% CI, 0.830-0.952; p < 0.001). A 1 m/s increase in walking pace 
      decreased the risk of T2DM by 90.0% (OR = 0.100; 95% CI, 0.053-0.186; p < 0.001). 
      The relationship was bidirectional, with T2DM as a causative factor of 
      sarcopenia-related traits (p < 0.05) except for ALM (beta = 0.018; 95% CI, -0.008 to 
      -0.044; p = 0.168). CONCLUSIONS: Hand-grip strength and T2DM had a potential 
      bidirectional causal relationship, as did walking pace and T2DM. We suggest that 
      sarcopenia and T2DM may mutually have a significant causal effect on each other.
CI  - Copyright (c) 2023 Chen, Yan, Aiheti, Kuribanjiang, Yao, Wang, Zhou and Yang.
FAU - Chen, Simin
AU  - Chen S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Yan, Shikang
AU  - Yan S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Aiheti, Nuerbiyamu
AU  - Aiheti N
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Kuribanjiang, Kaidiriyan
AU  - Kuribanjiang K
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Yao, Xuemei
AU  - Yao X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Zhou, Tao
AU  - Zhou T
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinjiang Medical University, Urumqi, Xinjiang, China.
AD  - State Key Laboratory of Causes and Prevention of High Morbidity in Central Asia 
      jointly established by the Ministry and the Province Urumqi, Xinjiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230308
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - *Sarcopenia/complications/epidemiology/genetics
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - Mendelian Randomization Analysis
MH  - Hand Strength
MH  - Phenotype
PMC - PMC10031051
OTO - NOTNLM
OT  - aging
OT  - appendicular lean mass
OT  - hand-grip strength
OT  - mendelian randomization
OT  - sarcopenia
OT  - type 2 diabetes mellitus
OT  - walking pace
COIS- We declare that the research was conducted in the absence of any commercial or 
      financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2023/03/28 06:00
MHDA- 2023/03/28 19:05
PMCR- 2023/01/01
CRDT- 2023/03/27 03:16
PHST- 2022/11/28 00:00 [received]
PHST- 2023/02/23 00:00 [accepted]
PHST- 2023/03/28 19:05 [medline]
PHST- 2023/03/27 03:16 [entrez]
PHST- 2023/03/28 06:00 [pubmed]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1109800 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Mar 8;14:1109800. doi: 
      10.3389/fendo.2023.1109800. eCollection 2023.