PMID- 36969700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230328
IS  - 2633-1055 (Electronic)
IS  - 2633-1055 (Linking)
VI  - 18
DP  - 2023
TI  - Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability 
      of Synchronous Neural Interactions.
PG  - 26331055231159658
LID - 10.1177/26331055231159658 [doi]
LID - 26331055231159658
AB  - Recent evidence documented a protective effect of Class II human leukocyte 
      antigen (HLA) DRB1*13 on brain health across the lifespan including evidence of 
      reduced neural network variability relative to non-carriers. Here, in an 
      extension of those findings, we evaluated the influence of a large number of 
      Class I and Class II HLA alleles on aging-related changes in neural network 
      variability. Cognitively healthy women (N = 178) ranging in age from 28 to 
      99 years old underwent a magnetoencephalography scan from which neural network 
      variability was calculated and provided a blood sample from which HLA and 
      apolipoprotein E (ApoE) genotype were determined. The primary analyses assessed 
      the dependence of network variability on age in carriers of a specific HLA allele 
      compared to non-carriers. Effects were considered protective if there was a 
      significant increase of network variability with age in the absence of a given 
      HLA allele but not in its presence, and were considered to confer susceptibility 
      if the converse was documented; HLA alleles that did not influence the dependence 
      of network variability on age in their presence or absence were considered 
      neutral. Of 50 alleles investigated, 22 were found to be protective, 7 were found 
      to confer susceptibility, and 21 were neutral. The frequencies of those 50 
      alleles were not associated significantly with ApoE genotype. The findings, which 
      document the influence of HLA on age-related brain changes and highlight the role 
      of HLA in healthy brain function, are discussed in terms of the role of HLA in 
      the human immune response to foreign antigens.
CI  - (c) The Author(s) 2023.
FAU - James, Lisa M
AU  - James LM
AUID- ORCID: 0000-0001-9021-0690
AD  - The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs 
      Health Care System, Minneapolis, MN, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Center for Cognitive Sciences, University of Minnesota, Minneapolis, MN, USA.
FAU - Leuthold, Arthur C
AU  - Leuthold AC
AD  - The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs 
      Health Care System, Minneapolis, MN, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AUID- ORCID: 0000-0003-4412-725X
AD  - The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs 
      Health Care System, Minneapolis, MN, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Center for Cognitive Sciences, University of Minnesota, Minneapolis, MN, USA.
AD  - Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20230323
PL  - United States
TA  - Neurosci Insights
JT  - Neuroscience insights
JID - 101760670
PMC - PMC10037734
OTO - NOTNLM
OT  - Human leukocyte antigen
OT  - aging
OT  - apolipoprotein E
OT  - magnetoencephalography
OT  - neural network
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/03/28 06:00
MHDA- 2023/03/28 06:01
PMCR- 2023/03/23
CRDT- 2023/03/27 03:41
PHST- 2022/08/08 00:00 [received]
PHST- 2023/02/08 00:00 [accepted]
PHST- 2023/03/27 03:41 [entrez]
PHST- 2023/03/28 06:00 [pubmed]
PHST- 2023/03/28 06:01 [medline]
PHST- 2023/03/23 00:00 [pmc-release]
AID - 10.1177_26331055231159658 [pii]
AID - 10.1177/26331055231159658 [doi]
PST - epublish
SO  - Neurosci Insights. 2023 Mar 23;18:26331055231159658. doi: 
      10.1177/26331055231159658. eCollection 2023.