PMID- 36971053
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20230613
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 111
IP  - 8
DP  - 2023 Aug
TI  - Effect of a modified adhesive system with encapsulated arginine and calcium 
      carbonate on dentin permeability.
PG  - 1546-1556
LID - 10.1002/jbm.b.35253 [doi]
AB  - To modify an adhesive system with halloysite clay nanotubes (HNTs) containing 
      arginine and calcium carbonate and to evaluate their cytocompatibility, viscosity 
      and efficacy in reducing dentin permeability. HNTs containing arginine and 
      calcium carbonate were incorporated into the primer and adhesive of a three-step 
      adhesive system (SBMP), and their viscosity was measured. Discs (n = 4/group) 
      were prepared: SBMP (control), HNT-PR (modified primer), HNT-ADH (modified 
      adhesive) and HNT-PR + ADH (modified primer and adhesive) were evaluated 
      regarding cell death and viability. Dentin discs were prepared and randomly 
      assigned into the following treatments (n = 10): NC (no treatment), SBMP, HNT-PR, 
      HNT-ADH, HNT-PR + ADH and COL (Colgate(R) Sensitive Pro-relief prophylaxis paste). 
      After, they were submitted to an erosive-abrasive cycling. Dentin permeability 
      (hydraulic conductance) was evaluated at baseline, 24 h after treatment and after 
      cycling. Both the modified primer and adhesive showed significantly higher 
      viscosity than their controls. Group HNT-PR resulted in significantly higher 
      cytotoxicity when compared to SBMP and HNT-PR + ADH groups. Group HNT-ADH 
      resulted in the highest cell viability compared to all other groups. All groups 
      showed significantly lower dentin permeability when compared to the NC group. 
      Post-cycling, SBMP and HNT-ADH groups showed significantly lower permeability 
      when compared to COL group. The addition of encapsulated arginine and calcium 
      carbonate did not affect the cytocompatibility of the materials nor their ability 
      to reduce dentin permeability.
CI  - (c) 2023 The Authors. Journal of Biomedical Materials Research Part B: Applied 
      Biomaterials published by Wiley Periodicals LLC.
FAU - AlShehri, Aram Mushabbab
AU  - AlShehri AM
AD  - Department of Biomedical Sciences and Comprehensive Care, Indiana University 
      School of Dentistry (IUSD), Indianapolis, Indiana, USA.
AD  - College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Kamocki, Krzysztof
AU  - Kamocki K
AD  - Department of Biomedical Sciences and Comprehensive Care, Indiana University 
      School of Dentistry (IUSD), Indianapolis, Indiana, USA.
FAU - Viana, Itallo Emidio Lira
AU  - Viana IEL
AUID- ORCID: 0000-0001-7252-6616
AD  - Department of Restorative Dentistry, School of Dentistry, University of Sao 
      Paulo, SP, Brazil.
FAU - Scaramucci, Tais
AU  - Scaramucci T
AUID- ORCID: 0000-0002-4445-6697
AD  - Department of Restorative Dentistry, School of Dentistry, University of Sao 
      Paulo, SP, Brazil.
FAU - Hara, Anderson
AU  - Hara A
AUID- ORCID: 0000-0001-9822-6064
AD  - Department of Cariology, Operative Dentistry and Dental Public Health, Indiana 
      University School of Dentistry (IUSD), Indianapolis, Indiana, USA.
FAU - Windsor, L Jack
AU  - Windsor LJ
AD  - Department of Biomedical Sciences and Comprehensive Care, Indiana University 
      School of Dentistry (IUSD), Indianapolis, Indiana, USA.
FAU - Platt, Jeffrey A
AU  - Platt JA
AD  - Department of Biomedical Sciences and Comprehensive Care, Indiana University 
      School of Dentistry (IUSD), Indianapolis, Indiana, USA.
FAU - Cook, Norman Blaine
AU  - Cook NB
AD  - Department of Cariology, Operative Dentistry and Dental Public Health, Indiana 
      University School of Dentistry (IUSD), Indianapolis, Indiana, USA.
FAU - Sochacki, Sabrina Feitosa
AU  - Sochacki SF
AUID- ORCID: 0000-0001-6689-9141
AD  - Department of Biomedical Sciences and Comprehensive Care, Indiana University 
      School of Dentistry (IUSD), Indianapolis, Indiana, USA.
LA  - eng
PT  - Journal Article
DEP - 20230327
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - H0G9379FGK (Calcium Carbonate)
RN  - 0 (Adhesives)
RN  - 94ZLA3W45F (Arginine)
RN  - T1FAD4SS2M (Clay)
SB  - IM
MH  - *Calcium Carbonate/pharmacology
MH  - *Adhesives/pharmacology
MH  - Arginine/pharmacology
MH  - Dentin Permeability
MH  - Clay
MH  - Dentin
MH  - Materials Testing
EDAT- 2023/03/28 06:00
MHDA- 2023/06/08 06:42
CRDT- 2023/03/27 05:15
PHST- 2023/02/22 00:00 [revised]
PHST- 2022/05/31 00:00 [received]
PHST- 2023/03/12 00:00 [accepted]
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/03/28 06:00 [pubmed]
PHST- 2023/03/27 05:15 [entrez]
AID - 10.1002/jbm.b.35253 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2023 Aug;111(8):1546-1556. doi: 
      10.1002/jbm.b.35253. Epub 2023 Mar 27.