PMID- 36971931
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 20
DP  - 2023 Apr
TI  - Exposure to perfluoroalkyl and polyfluoroalkyl substances and estimated 
      glomerular filtration rate in adults: a cross-sectional study based on NHANES 
      (2017-2018).
PG  - 57931-57944
LID - 10.1007/s11356-023-26384-9 [doi]
AB  - Perfluoroalkyl and polyfluoroalkyl substances (PFASs) may be important 
      environmental risk factors affecting renal function. This study aimed to 
      investigate the relationships between PFASs and estimated glomerular filtration 
      rate (eGFR) in univariate exposure and multivariate co-exposure models of PFASs. 
      A total of 1700 people over 18 years from National Health and Nutrition 
      Examination Survey (NHANES) in 2017-2018 were selected as subjects to explore the 
      relationships between eGFR and six PFASs (perfluorooctanoic acid (PFOA), 
      perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), 
      perfluorodecanoic acid (PFUA), perfluorodecanoic acid (PFDeA), and 
      perfluorohexane sulfonate (PFHxS)). First, multiple linear regression was used to 
      estimate the association of each PFAS with eGFR, and the joint effect of PFAS 
      mixtures was evaluated by Bayesian kernel machine regression (BKMR). Multiple 
      linear regression analysis showed PFOS (beta =  - 0.246, p = 0.026) and PFHxS 
      (beta = 0.538, p = 0.049) were significantly associated with eGFR in total 
      population. In BKMR analysis, there was joint effect between PFOS and PFHxS for 
      eGFR. And there were the joint effects of multiple PFAS on eGFR, especially the 
      significant joint effect between PFHxS and PFDeA/PFNA/PFUA. Future cohort studies 
      need to explore the association of multiple PFASs and health.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Liang, Yufen
AU  - Liang Y
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China.
FAU - Zhou, Han
AU  - Zhou H
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China.
FAU - Zhang, Jiachen
AU  - Zhang J
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China.
FAU - Li, Shuangjing
AU  - Li S
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China.
FAU - Shen, Weitong
AU  - Shen W
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China.
FAU - Lei, Lijian
AU  - Lei L
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan, 030001, China. wwdlijian@sxmu.edu.cn.
LA  - eng
GR  - 81872701/National Natural Science Foundation of China/
GR  - 81273040/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230327
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 335-76-2 (perfluorodecanoic acid)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 375-95-1 (perfluoro-n-nonanoic acid)
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Alkanesulfonates)
RN  - FX3WJ41CMX (perflexane)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Environmental Pollutants/adverse effects
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Glomerular Filtration Rate
MH  - Bayes Theorem
MH  - *Fluorocarbons
MH  - *Alkanesulfonic Acids
MH  - Alkanesulfonates
OTO - NOTNLM
OT  - Adults
OT  - Bayesian kernel machine regression
OT  - Estimated glomerular filtration rate
OT  - National Health and Nutrition Examination Survey
OT  - Overall effect
OT  - Perfluoroalkyl and polyfluoroalkyl substances
EDAT- 2023/03/28 06:00
MHDA- 2023/05/10 06:42
CRDT- 2023/03/27 11:20
PHST- 2022/07/14 00:00 [received]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/03/28 06:00 [pubmed]
PHST- 2023/03/27 11:20 [entrez]
AID - 10.1007/s11356-023-26384-9 [pii]
AID - 10.1007/s11356-023-26384-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Apr;30(20):57931-57944. doi: 
      10.1007/s11356-023-26384-9. Epub 2023 Mar 27.