PMID- 36971937
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 20
DP  - 2023 Apr
TI  - Association of the urinary polycyclic aromatic hydrocarbons with sex hormones 
      stratified by menopausal status older than 20 years: a mixture analysis.
PG  - 57717-57727
LID - 10.1007/s11356-023-26099-x [doi]
AB  - We examined the relationships between exposure to polycyclic aromatic 
      hydrocarbons (PAH) metabolites and sex hormones in pre- and postmenopausal women 
      from the 2013-2016 National Health and Nutrition Examination Survey. The study 
      comprised 648 premenopausal and 370 postmenopausal women (aged 20 years or older) 
      with comprehensive data on PAH metabolites and sex steroid hormones. To evaluate 
      the correlations between individual or mixture of the PAH metabolites and sex 
      hormones stratified by menopausal status, we used linear regression and Bayesian 
      kernel machine regression (BKMR). After controlling for confounders, 
      1-Hydroxynaphthalene (1-NAP) was inversely associated with total testosterone 
      (TT), and 1-NAP, 3-Hydroxyfluorene (3-FLU), and 2-Hydroxyfluorene (2-FLU) were 
      inversely associated with estradiol (E2). 3-FLU was positively associated with 
      sex hormone-binding globulin (SHBG) and TT/E2, whereas 1-NAP and 2-FLU were 
      inversely associated with free androgen index (FAI). In the BKMR analyses, 
      chemical combination concentrations at or above the 55th percentile were 
      inversely connected to E2, TT, and FAI values but positively correlated with SHBG 
      when compared with the matching 50th percentile. In addition, we only found that 
      mixed exposure to PAHs was positively associated with TT and SHBG in 
      premenopausal women. Exposure to PAH metabolites, either alone or as a mixture, 
      was negatively associated with E2, TT, FAI, and TT/E2 but positively associated 
      with SHBG. These associations were stronger among postmenopausal women.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhu, Xihui
AU  - Zhu X
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Meng, Yancen
AU  - Meng Y
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Ju, Yaru
AU  - Ju Y
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Yang, Yanjing
AU  - Yang Y
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Zhang, Su'e
AU  - Zhang S
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Miao, Liye
AU  - Miao L
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China.
FAU - Liu, Zhan
AU  - Liu Z
AD  - Department of Perinatal Center, The Fourth Hospital of Shijiazhuang/Shijiazhuang 
      Obstetrics and Gynecology Hospital, Shijiazhuang, China. lzhanyy@163.com.
LA  - eng
GR  - 201461173/Shijiazhuang science and technology research and development plan 
      project/
PT  - Journal Article
DEP - 20230327
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Polycyclic Aromatic Hydrocarbons
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Gonadal Steroid Hormones
MH  - Testosterone
MH  - Menopause
OTO - NOTNLM
OT  - Menopause
OT  - NHANES
OT  - Polycyclic aromatic hydrocarbons
OT  - Sex hormones
EDAT- 2023/03/28 06:00
MHDA- 2023/05/10 06:42
CRDT- 2023/03/27 11:20
PHST- 2022/12/27 00:00 [received]
PHST- 2023/02/20 00:00 [accepted]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/03/28 06:00 [pubmed]
PHST- 2023/03/27 11:20 [entrez]
AID - 10.1007/s11356-023-26099-x [pii]
AID - 10.1007/s11356-023-26099-x [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Apr;30(20):57717-57727. doi: 
      10.1007/s11356-023-26099-x. Epub 2023 Mar 27.