PMID- 36972877 OWN - NLM STAT- MEDLINE DCOM- 20230517 LR - 20230517 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 879 DP - 2023 Jun 25 TI - Associations of perchlorate, nitrate, and thiocyanate with metabolic syndrome and its components among US adults: A cross-sectional study from NHANES. PG - 163083 LID - S0048-9697(23)01702-3 [pii] LID - 10.1016/j.scitotenv.2023.163083 [doi] AB - Perchlorate, nitrate and thiocyanate are common endocrine disruptors. Herein, this study was undertaken to evaluate the associations between perchlorate, nitrate, and thiocyanate exposures (alone or in combination) and risk of metabolic syndrome (MetS) among adults, which has not been explored so far. Analytical data were extracted from different datasets in the National Health and Nutrition Examination Survey (NHANES) database. Multivariate logistic regression models were constructed to investigate the associations between perchlorate, nitrate, and thiocyanate exposures, and the prevalence of MetS. Subsequently, odds ratios (OR) and their corresponding 95 % confidence intervals (CIs) were adopted to represent the magnitude of the effect size. We performed a series of subgroup analyses and sensitivity analyses as well. Moreover, three commonly used mixture modeling strategies [Weighted quantile sum (WQS) regression, quantile-based g-computation (Qgcomp), and Bayesian kernel machine regression (BKMR)] were utilized to evaluate the joint mixture effect on MetS. This study included 12,007 participants in the subsequent analyses. After adjustment for confounding factors, higher levels of perchlorate, and thiocyanate concentrations were significantly associated with the risk of MetS (OR = 1.15, 95%CI:1.00, 1.32; OR = 1.21, 95%CI:1.04, 1.41, respectively). Analyses of WQS and Qgcomp showed that a quartile increase in chemical mixture was correlated with the occurrence of MetS with ORs of 1.07 (95%CI: 0.99, 1.16) and 1.07 (95%CI: 1.00, 1.14), respectively. This positive association was mainly driven by perchlorate and thiocyanate. Analysis of BKMR revealed that perchlorate, nitrate, and thiocyanate mixture was positively associated with the risk of MetS while perchlorate, and thiocyanate were major predictors in the mixture. In summary, our study reveals positive relationships between perchlorate, thiocyanate and MetS. Co-exposure to perchlorate, nitrate and thiocyanate is positively associated with the risk of MetS, with perchlorate and thiocyanate contributing the most to the overall mixture effect. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - Guo, Xianwei AU - Guo X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Wu, Birong AU - Wu B AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Hu, Wenjing AU - Hu W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Wang, Xingyue AU - Wang X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Su, Wenqi AU - Su W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Meng, Jia AU - Meng J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Lowe, Scott AU - Lowe S AD - College of Osteopathic Medicine, Kansas City University, Kansas City, MO 64106, USA. FAU - Zhao, Dongdong AU - Zhao D AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Huang, Christy AU - Huang C AD - Touro University Nevada College of Osteopathic Medicine, 874 American Pacific Dr, Henderson, NV 89014, USA. FAU - Liang, Mingming AU - Liang M AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Qu, Guangbo AU - Qu G AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. Electronic address: m17356519870@163.com. FAU - Zhou, Xiaoqin AU - Zhou X AD - Chaohu Hospital, Anhui Medical University, No. 64 Chaohubei Road, Hefei 238000, Anhui, China. FAU - Sun, Yehuan AU - Sun Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China; Chaohu Hospital, Anhui Medical University, No. 64 Chaohubei Road, Hefei 238000, Anhui, China. Electronic address: yhsun_ahmu_edu@yeah.net. LA - eng PT - Journal Article DEP - 20230325 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Nitrates) RN - VLA4NZX2P4 (perchlorate) RN - 0 (Perchlorates) RN - O748SU14OM (thiocyanate) RN - 0 (Thiocyanates) SB - IM MH - Humans MH - Adult MH - *Nitrates MH - Nutrition Surveys MH - Cross-Sectional Studies MH - *Metabolic Syndrome/chemically induced/epidemiology MH - Perchlorates MH - Thiocyanates MH - Bayes Theorem OTO - NOTNLM OT - MetS OT - Mixture OT - NHANES OT - Nitrate OT - Perchlorate OT - Thiocyanate COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/03/28 06:00 MHDA- 2023/05/17 06:42 CRDT- 2023/03/27 20:26 PHST- 2022/12/01 00:00 [received] PHST- 2023/02/27 00:00 [revised] PHST- 2023/03/22 00:00 [accepted] PHST- 2023/05/17 06:42 [medline] PHST- 2023/03/28 06:00 [pubmed] PHST- 2023/03/27 20:26 [entrez] AID - S0048-9697(23)01702-3 [pii] AID - 10.1016/j.scitotenv.2023.163083 [doi] PST - ppublish SO - Sci Total Environ. 2023 Jun 25;879:163083. doi: 10.1016/j.scitotenv.2023.163083. Epub 2023 Mar 25.